Literature DB >> 15713904

Marine natural products as anticancer drugs.

T Luke Simmons1, Eric Andrianasolo, Kerry McPhail, Patricia Flatt, William H Gerwick.   

Abstract

The chemical and biological diversity of the marine environment is immeasurable and therefore is an extraordinary resource for the discovery of new anticancer drugs. Recent technological and methodologic advances in structure elucidation, organic synthesis, and biological assay have resulted in the isolation and clinical evaluation of various novel anticancer agents. These compounds range in structural class from simple linear peptides, such as dolastatin 10, to complex macrocyclic polyethers, such as halichondrin B; equally as diverse are the molecular modes of action by which these molecules impart their biological activity. This review highlights several marine natural products and their synthetic derivatives that are currently undergoing clinical evaluation as anticancer drugs.

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Year:  2005        PMID： 15713904

Source DB:  PubMed          Journal:  Mol Cancer Ther        ISSN： 1535-7163            Impact factor:   6.261


  148 in total

1.  Apoptosis-inducing activities of Halopteris scoparia L. Sauvageau (Brown algae) on cancer cells and its biosafety and antioxidant properties.

Authors:  Adem Güner; Ayşe Nalbantsoy; Atakan Sukatar; Nefise Ülkü Karabay Yavaşoğlu
Journal:  Cytotechnology       Date:  2019-04-09       Impact factor: 2.058

2.  A distinctive structural twist in the aminoimidazole alkaloids from a calcareous marine sponge: isolation and characterization of leucosolenamines A and B.

Authors:  Paul Ralifo; Karen Tenney; Frederick A Valeriote; Phillip Crews
Journal:  J Nat Prod       Date:  2007-01       Impact factor: 4.050

Review 3.  Sponge-associated microorganisms: evolution, ecology, and biotechnological potential.

Authors:  Michael W Taylor; Regina Radax; Doris Steger; Michael Wagner
Journal:  Microbiol Mol Biol Rev       Date:  2007-06       Impact factor: 11.056

4.  Biosynthetic origin of natural products isolated from marine microorganism-invertebrate assemblages.

Authors:  T Luke Simmons; R Cameron Coates; Benjamin R Clark; Niclas Engene; David Gonzalez; Eduardo Esquenazi; Pieter C Dorrestein; William H Gerwick
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-04       Impact factor: 11.205

Review 5.  Natural products as leads to anticancer drugs.

Authors:  M Gordaliza
Journal:  Clin Transl Oncol       Date:  2007-12       Impact factor: 3.405

6.  Site-specific chemical modification of antibody fragments using traceless cleavable linkers.

Authors:  Gonçalo J L Bernardes; Martina Steiner; Isabelle Hartmann; Dario Neri; Giulio Casi
Journal:  Nat Protoc       Date:  2013-10-03       Impact factor: 13.491

7.  Marine natural products: a new wave of drugs?

Authors:  Rana Montaser; Hendrik Luesch
Journal:  Future Med Chem       Date:  2011-09       Impact factor: 3.808

8.  Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting.

Authors:  Feng Zhu; Chu Qin; Lin Tao; Xin Liu; Zhe Shi; Xiaohua Ma; Jia Jia; Ying Tan; Cheng Cui; Jinshun Lin; Chunyan Tan; Yuyang Jiang; Yuzong Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2011-07-18       Impact factor: 11.205

9.  Characterization of the saframycin A gene cluster from Streptomyces lavendulae NRRL 11002 revealing a nonribosomal peptide synthetase system for assembling the unusual tetrapeptidyl skeleton in an iterative manner.

Authors:  Lei Li; Wei Deng; Jie Song; Wei Ding; Qun-Fei Zhao; Chao Peng; Wei-Wen Song; Gong-Li Tang; Wen Liu
Journal:  J Bacteriol       Date:  2007-11-02       Impact factor: 3.490

Review 10.  Strategies for the synthesis of the novel antitumor agent peloruside A.

Authors:  David R Williams; Partha P Nag; Nicolas Zorn
Journal:  Curr Opin Drug Discov Devel       Date:  2008-03
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