| Literature DB >> 15713402 |
David S Weinstein1, Wen Liu, Zhengxiang Gu, Charles Langevine, Khehyong Ngu, Leena Fadnis, Donald W Combs, Doree Sitkoff, Saleem Ahmad, Shaobin Zhuang, Xing Chen, Feng-Lai Wang, Deborah A Loughney, Karnail S Atwal, Robert Zahler, John E Macor, Cort S Madsen, Natesan Murugesan.
Abstract
A series of inhibitors of mammalian 15-lipoxygenase based on tryptamine and homotryptamine scaffolds is described. Compounds with aryl substituents at C-2 of the indole core of tryptamine and homotryptamine sulfonamides (e.g., 37a-p) proved to be potent inhibitors of the isolated enzyme. Selected compounds also demonstrated desirable inhibition selectivities over isozymes 5- and P-12-LO.Entities:
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Year: 2005 PMID： 15713402 DOI： 10.1016/j.bmcl.2004.12.081
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823