Literature DB >> 25495979

The potential of 12/15-lipoxygenase inhibitors in stroke therapy.

Klaus van Leyen1, Theodore R Holman, David J Maloney.   

Abstract

Entities:  

Keywords:  edema; eicosanoid; hemorrhage; ischemia; lipoxygenase; oxidative stress; stroke; tissue plasminogen activator

Mesh：

Substances：

Year:  2014        PMID： 25495979      PMCID： PMC4280907          DOI： 10.4155/fmc.14.129

Source DB:  PubMed          Journal:  Future Med Chem        ISSN： 1756-8919            Impact factor:   3.808


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  20 in total

1.  Heart disease and stroke statistics--2014 update: a report from the American Heart Association.

Authors:  Alan S Go; Dariush Mozaffarian; Véronique L Roger; Emelia J Benjamin; Jarett D Berry; Michael J Blaha; Shifan Dai; Earl S Ford; Caroline S Fox; Sheila Franco; Heather J Fullerton; Cathleen Gillespie; Susan M Hailpern; John A Heit; Virginia J Howard; Mark D Huffman; Suzanne E Judd; Brett M Kissela; Steven J Kittner; Daniel T Lackland; Judith H Lichtman; Lynda D Lisabeth; Rachel H Mackey; David J Magid; Gregory M Marcus; Ariane Marelli; David B Matchar; Darren K McGuire; Emile R Mohler; Claudia S Moy; Michael E Mussolino; Robert W Neumar; Graham Nichol; Dilip K Pandey; Nina P Paynter; Matthew J Reeves; Paul D Sorlie; Joel Stein; Amytis Towfighi; Tanya N Turan; Salim S Virani; Nathan D Wong; Daniel Woo; Melanie B Turner
Journal:  Circulation       Date:  2013-12-18       Impact factor: 29.690

2.  Structure-activity relationship studies of nordihydroguaiaretic acid inhibitors toward soybean, 12-human, and 15-human lipoxygenase.

Authors:  Stephanie Whitman; Mikail Gezginci; Barbara N Timmermann; Theodore R Holman
Journal:  J Med Chem       Date:  2002-06-06       Impact factor: 7.446

3.  Probing sponge-derived terpenoids for human 15-lipoxygenase inhibitors.

Authors:  J Carroll; E N Jonsson; R Ebel; M S Hartman; T R Holman; P Crews
Journal:  J Org Chem       Date:  2001-10-19       Impact factor: 4.354

4.  Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1.

Authors:  Ganesha Rai; Victor Kenyon; Ajit Jadhav; Lena Schultz; Michelle Armstrong; J Brian Jameson; Eric Hoobler; William Leister; Anton Simeonov; Theodore R Holman; David J Maloney
Journal:  J Med Chem       Date:  2010-10-28       Impact factor: 7.446

5.  Pyrazole-based sulfonamide and sulfamides as potent inhibitors of mammalian 15-lipoxygenase.

Authors:  Khehyong Ngu; David S Weinstein; Wen Liu; Charles Langevine; Donald W Combs; Shaobin Zhuang; Xing Chen; Cort S Madsen; Timothy W Harper; Saleem Ahmad; Jeffrey A Robl
Journal:  Bioorg Med Chem Lett       Date:  2011-06-06       Impact factor: 2.823

6.  Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases.

Authors:  Taro Amagata; Stephanie Whitman; Tyler A Johnson; Chad C Stessman; Christopher P Loo; Emil Lobkovsky; Jon Clardy; Phillip Crews; Theodore R Holman
Journal:  J Nat Prod       Date:  2003-02       Impact factor: 4.050

7.  Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration.

Authors:  Savita Khanna; Sashwati Roy; Hoon Ryu; Praveen Bahadduri; Peter W Swaan; Rajiv R Ratan; Chandan K Sen
Journal:  J Biol Chem       Date:  2003-08-13       Impact factor: 5.157

8.  Inhibition by dietary curcumin of azoxymethane-induced ornithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism and aberrant crypt foci formation in the rat colon.

Authors:  C V Rao; B Simi; B S Reddy
Journal:  Carcinogenesis       Date:  1993-11       Impact factor: 4.944

9.  Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke.

Authors:  Kazim Yigitkanli; Anton Pekcec; Hulya Karatas; Stefanie Pallast; Emiri Mandeville; Netra Joshi; Natalya Smirnova; Irina Gazaryan; Rajiv R Ratan; Joseph L Witztum; Joan Montaner; Theodore R Holman; Eng H Lo; Klaus van Leyen
Journal:  Ann Neurol       Date:  2012-11-28       Impact factor: 10.422

10.  Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies.

Authors:  Ganesha Rai; Netra Joshi; Joo Eun Jung; Yu Liu; Lena Schultz; Adam Yasgar; Steve Perry; Giovanni Diaz; Qiangli Zhang; Victor Kenyon; Ajit Jadhav; Anton Simeonov; Eng H Lo; Klaus van Leyen; David J Maloney; Theodore R Holman
Journal:  J Med Chem       Date:  2014-05-13       Impact factor: 7.446
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  11 in total

1.  A potent and selective inhibitor targeting human and murine 12/15-LOX.

Authors:  Michelle M Armstrong; Cody J Freedman; Joo Eun Jung; Yi Zheng; Chakrapani Kalyanaraman; Matthew P Jacobson; Anton Simeonov; David J Maloney; Klaus van Leyen; Ajit Jadhav; Theodore R Holman
Journal:  Bioorg Med Chem       Date:  2016-01-21       Impact factor: 3.641

Review 2.  Biomarkers of Oxidative Stress Tethered to Cardiovascular Diseases.

Authors:  Poojarani Panda; Henu Kumar Verma; Saikrishna Lakkakula; Neha Merchant; Fairrul Kadir; Shamsur Rahman; Mohammad Saffree Jeffree; Bhaskar V K S Lakkakula; Pasupuleti Visweswara Rao
Journal:  Oxid Med Cell Longev       Date:  2022-06-24       Impact factor: 7.310

Review 3.  The Chemical Biology of Ferroptosis in the Central Nervous System.

Authors:  Rajiv R Ratan
Journal:  Cell Chem Biol       Date:  2020-04-02       Impact factor: 8.116

4.  Inhibiting 12/15-lipoxygenase to treat acute stroke in permanent and tPA induced thrombolysis models.

Authors:  H Karatas; Joo Eun Jung; E H Lo; K van Leyen
Journal:  Brain Res       Date:  2017-10-24       Impact factor: 3.252

Review 5.  Role of the 12-lipoxygenase pathway in diabetes pathogenesis and complications.

Authors:  A D Dobrian; M A Morris; D A Taylor-Fishwick; T R Holman; Y Imai; R G Mirmira; J L Nadler
Journal:  Pharmacol Ther       Date:  2018-10-19       Impact factor: 12.310

Review 6.  Oxidized phospholipid signaling in traumatic brain injury.

Authors:  Tamil S Anthonymuthu; Elizabeth M Kenny; Andrew M Lamade; Valerian E Kagan; Hülya Bayır
Journal:  Free Radic Biol Med       Date:  2018-06-30       Impact factor: 7.376

Review 7.  Role of Ferroptosis in Stroke.

Authors:  Yunfei Xu; Kexin Li; Yao Zhao; Lin Zhou; Ying Liu; Jie Zhao
Journal:  Cell Mol Neurobiol       Date:  2022-01-31       Impact factor: 5.046

Review 8.  Baicalein, Baicalin, and Wogonin: Protective Effects against Ischemia-Induced Neurodegeneration in the Brain and Retina.

Authors:  Li Pan; Kin-Sang Cho; Irvin Yi; Chi-Ho To; Dong Feng Chen; Chi-Wai Do
Journal:  Oxid Med Cell Longev       Date:  2021-06-29       Impact factor: 7.310

9.  Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models.

Authors:  Saravanan S Karuppagounder; Ishraq Alim; Soah J Khim; Megan W Bourassa; Sama F Sleiman; Roseleen John; Cyrille C Thinnes; Tzu-Lan Yeh; Marina Demetriades; Sandra Neitemeier; Dana Cruz; Irina Gazaryan; David W Killilea; Lewis Morgenstern; Guohua Xi; Richard F Keep; Timothy Schallert; Ryan V Tappero; Jian Zhong; Sunghee Cho; Frederick R Maxfield; Theodore R Holman; Carsten Culmsee; Guo-Hua Fong; Yijing Su; Guo-li Ming; Hongjun Song; John W Cave; Christopher J Schofield; Frederick Colbourne; Giovanni Coppola; Rajiv R Ratan
Journal:  Sci Transl Med       Date:  2016-03-02       Impact factor: 17.956

Review 10.  Ferroptosis and Its Multifaceted Roles in Cerebral Stroke.

Authors:  Yongfa Zhang; Xiaoyang Lu; Bai Tai; Weijia Li; Tao Li
Journal:  Front Cell Neurosci       Date:  2021-06-03       Impact factor: 5.505
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