Rebecca Hardy1, Diana Kuh. 1. MRC National Survey of Health and Development, Department of Epidemiology and Public Health, Royal Free and University College Medical School, London WC1E 6BT, UK.
Abstract
OBJECTIVE: To assess whether socio-economic status, environmental stress and hardship throughout the life course are associated with age at menopause. DESIGN: Birth cohort study. SETTING: England, Scotland, Wales. SAMPLE: A total of 1515 women from a stratified sample of all births in one week in 1946. METHODS: Age at menopause was collected using annual postal questionnaires from age 47 to 53 years. Information on socio-economic conditions and hardship were collected at contacts throughout life from age 2 to 43 years. Socio-economic indicator variables were defined to represent cumulative exposure to hardship in childhood and in adulthood. MAIN OUTCOME MEASURES: Age at menopause. RESULTS: Cox's proportional hazard models indicated that women whose fathers were in a manual social class occupation at three time points during her childhood had an earlier age at menopause than those whose fathers were in non-manual occupations at all three (HR: 1.51; 95% CI: 0.93-2.47). Similar findings were seen for household crowding. These socio-economic gradients could not be explained by adult socio-economic status, behaviour and lifestyle or by psychological health and stress, but were attenuated by other early life factors. Women who experienced parental divorce early in life (before five years of age) had double the rate of menopause of those whose parents did not divorce (HR: 2.14; 95% CI: 1.33-3.42). There were no consistent findings with adult socio-economic indicators. CONCLUSIONS: There is some evidence of a cumulative effect of socio-economic circumstances in childhood, but not in adulthood, on age at menopause. Childhood nutrition, cognition and emotional stress possibly underlie the social gradient.
OBJECTIVE: To assess whether socio-economic status, environmental stress and hardship throughout the life course are associated with age at menopause. DESIGN: Birth cohort study. SETTING: England, Scotland, Wales. SAMPLE: A total of 1515 women from a stratified sample of all births in one week in 1946. METHODS: Age at menopause was collected using annual postal questionnaires from age 47 to 53 years. Information on socio-economic conditions and hardship were collected at contacts throughout life from age 2 to 43 years. Socio-economic indicator variables were defined to represent cumulative exposure to hardship in childhood and in adulthood. MAIN OUTCOME MEASURES: Age at menopause. RESULTS:Cox's proportional hazard models indicated that women whose fathers were in a manual social class occupation at three time points during her childhood had an earlier age at menopause than those whose fathers were in non-manual occupations at all three (HR: 1.51; 95% CI: 0.93-2.47). Similar findings were seen for household crowding. These socio-economic gradients could not be explained by adult socio-economic status, behaviour and lifestyle or by psychological health and stress, but were attenuated by other early life factors. Women who experienced parental divorce early in life (before five years of age) had double the rate of menopause of those whose parents did not divorce (HR: 2.14; 95% CI: 1.33-3.42). There were no consistent findings with adult socio-economic indicators. CONCLUSIONS: There is some evidence of a cumulative effect of socio-economic circumstances in childhood, but not in adulthood, on age at menopause. Childhood nutrition, cognition and emotional stress possibly underlie the social gradient.
Authors: Ellen B Gold; Sybil L Crawford; Nancy E Avis; Carolyn J Crandall; Karen A Matthews; L Elaine Waetjen; Jennifer S Lee; Rebecca Thurston; Marike Vuga; Siobán D Harlow Journal: Am J Epidemiol Date: 2013-06-20 Impact factor: 4.897
Authors: Morgan E Levine; Ake T Lu; Brian H Chen; Dena G Hernandez; Andrew B Singleton; Luigi Ferrucci; Stefania Bandinelli; Elias Salfati; JoAnn E Manson; Austin Quach; Cynthia D J Kusters; Diana Kuh; Andrew Wong; Andrew E Teschendorff; Martin Widschwendter; Beate R Ritz; Devin Absher; Themistocles L Assimes; Steve Horvath Journal: Proc Natl Acad Sci U S A Date: 2016-07-25 Impact factor: 11.205