| Literature DB >> 15710503 |
Y Ueno1, H Futagawa, Y Takagi, A Ueno, Y Mizushima.
Abstract
We devised a simple method for incorporating drugs into solid calcium carbonate nanoparticles (nano-CaCO3). The size of nano-CaCO3 was controlled by mixing speed. Washing the nanoparticles released little incorporated drug but much drug that was adsorbed on the surface. In an in vitro releasing test, granulocyte colony-stimulating factor incorporated in nano-CaCO3 was chemically stable and released very slowly. Subcutaneous injection of nano-CaCO3 incorporating betamethasone phosphate (BP) resulted in a smaller initial increase in plasma concentration and a subsequent sustained release in compared with betamethasone phosphate solution. Nano-CaCO3 may be useful to deliver hydrophilic drugs and bioactive proteins.Entities:
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Year: 2004 PMID： 15710503 DOI： 10.1016/j.jconrel.2004.11.015
Source DB: PubMed Journal: J Control Release ISSN： 0168-3659 Impact factor: 9.776