| Literature DB >> 15705644 |
Judith N Steenbergen1, Jeff Alder, Grace M Thorne, Francis P Tally.
Abstract
Infections caused by drug-resistant pathogens are on the rise. Daptomycin, a cyclic lipopeptide with activity against most Gram-positive pathogens, including vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus, is a newly US-FDA approved antimicrobial for complicated skin and skin structure infections (cSSSI). Daptomycin has a unique mechanism of action that results in destruction of the membrane potential. The rapid bactericidal activity of daptomycin makes it an attractive antibiotic for serious Gram-positive infections.Entities:
Mesh:
Substances:
Year: 2005 PMID: 15705644 DOI: 10.1093/jac/dkh546
Source DB: PubMed Journal: J Antimicrob Chemother ISSN: 0305-7453 Impact factor: 5.790