| Literature DB >> 17220402 |
Kim Credito1, Gengrong Lin, Peter C Appelbaum.
Abstract
The synergistic effects of daptomycin plus gentamicin or rifampin were tested against 50 Staphylococcus aureus strains, with daptomycin MICs ranging between 0.25 and 8 microg/ml. Daptomycin sub-MICs combined with gentamicin concentrations lower than the MIC yielded synergy in 34 (68%) of the 50 strains. Daptomycin combined with rifampin yielded synergy in one vancomycin-intermediate S. aureus strain only, and virtually all synergy occurred between daptomycin and gentamicin.Entities:
Mesh:
Substances:
Year: 2007 PMID: 17220402 PMCID: PMC1855505 DOI: 10.1128/AAC.01455-06
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191