Literature DB >> 15703793

Synthesis and photochemical properties of photoactivated antitumor prodrugs releasing 5-fluorouracil.

Zhouen Zhang1, Hiroshi Hatta, Takeo Ito, Sei-ichi Nishimoto.   

Abstract

A new family of antitumor prodrugs (1-3) of 5-fluorouracil (5-FU) possessing photolabile 2-nitrobenzyl chromophores have been designed and synthesized to investigate the efficiency and mechanism of photoactivated 5-FU release upon UV-irradiation at lambda(ex)= 365 nm. The photoactivated prodrug 3 derived from conjugation of 2 with a tumor-homing cyclic peptide Cys-Asn-Gly-Arg-Cys (CNGRC) was so designed as to manifest a tumor-targeting function.

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Year:  2005        PMID： 15703793     DOI： 10.1039/b417734g

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  6 in total

1.  Synthesis and evaluation of novel Tc-99m labeled probestin conjugates for imaging APN/CD13 expression in vivo.

Authors:  Gopal Pathuri; Andria F Hedrick; Bryan C Disch; John T Doan; Michael A Ihnat; Vibhudutta Awasthi; Hariprasad Gali
Journal:  Bioconjug Chem       Date:  2011-12-20       Impact factor: 4.774

2.  The Issue of Tissue: Approaches and Challenges to the Light Control of Drug Activity: A Mini-Review.

Authors:  Mayank Sharma; Simon H Friedman
Journal:  ChemPhotoChem       Date:  2021-03-10

3.  Photoregulated release of caged anticancer drugs from gold nanoparticles.

Authors:  Sarit S Agasti; Apiwat Chompoosor; Chang-Cheng You; Partha Ghosh; Chae Kyu Kim; Vincent M Rotello
Journal:  J Am Chem Soc       Date:  2009-04-29       Impact factor: 15.419

Review 4.  Development of Photoremovable Linkers as a Novel Strategy to Improve the Pharmacokinetics of Drug Conjugates and Their Potential Application in Antibody-Drug Conjugates for Cancer Therapy.

Authors:  Audrey Nathania Johan; Yi Li
Journal:  Pharmaceuticals (Basel)       Date:  2022-05-25

5.  In Vivo Tumor Growth Inhibition and Antiangiogenic Effect of Cyclic NGR Peptide-Daunorubicin Conjugates Developed for Targeted Drug Delivery.

Authors:  Andrea Angelo Pierluigi Tripodi; Ivan Ranđelović; Beáta Biri-Kovács; Bálint Szeder; Gábor Mező; József Tóvári
Journal:  Pathol Oncol Res       Date:  2019-12-09       Impact factor: 3.201

Review 6.  Radiation- and photo-induced activation of 5-fluorouracil prodrugs as a strategy for the selective treatment of solid tumors.

Authors:  Takeo Ito; Kazuhito Tanabe; Hisatsugu Yamada; Hiroshi Hatta; Sei-ichi Nishimoto
Journal:  Molecules       Date:  2008-10-01       Impact factor: 4.411
  6 in total

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