Literature DB >> 15702370

The enantiomer of cholesterol.

E J Westover1, D F Covey.   

Abstract

Cholesterol plays a variety of significant roles in biological systems. However, the mechanisms by which cholesterol functions remain largely unclear. The enantiomer of cholesterol (ent-cholesterol)--which has identical physical properties, but opposite three-dimensional configuration compared to cholesterol--is a unique tool that can be used to better understand the mechanisms of cholesterol function. We review the literature pertaining to ent-cholesterol, focusing in particular on its use in biological studies.

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Year:  2004        PMID： 15702370     DOI： 10.1007/s00232-004-0714-7

Source DB:  PubMed          Journal:  J Membr Biol        ISSN： 0022-2631            Impact factor:   1.843


  55 in total

1.  A new model for protein stereospecificity.

Authors:  A D Mesecar; D E Koshland
Journal:  Nature       Date:  2000-02-10       Impact factor: 49.962

2.  Differential interaction of the two cholesterol-dependent, membrane-damaging toxins, streptolysin O and Vibrio cholerae cytolysin, with enantiomeric cholesterol.

Authors:  Alexander Zitzer; Emily J Westover; Douglas F Covey; Michael Palmer
Journal:  FEBS Lett       Date:  2003-10-23       Impact factor: 4.124

Review 3.  Koch's postulates for cholesterol.

Authors:  M S Brown; J L Goldstein
Journal:  Cell       Date:  1992-10-16       Impact factor: 41.582

4.  Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs.

Authors:  R B Rawson; N G Zelenski; D Nijhawan; J Ye; J Sakai; M T Hasan; T Y Chang; M S Brown; J L Goldstein
Journal:  Mol Cell       Date:  1997-12       Impact factor: 17.970

Review 5.  Related membrane domains in proteins of sterol sensing and cell signaling provide a glimpse of treasures still buried within the dynamic realm of intracellular metabolic regulation.

Authors:  T F Osborne; J M Rosenfeld
Journal:  Curr Opin Lipidol       Date:  1998-04       Impact factor: 4.776

Review 6.  Amphotericin B: new life for an old drug.

Authors:  S Hartsel; J Bolard
Journal:  Trends Pharmacol Sci       Date:  1996-12       Impact factor: 14.819

7.  Clinical phenotype of desmosterolosis.

Authors:  D R FitzPatrick; J W Keeling; M J Evans; A E Kan; J E Bell; M E Porteous; K Mills; R M Winter; P T Clayton
Journal:  Am J Med Genet       Date:  1998-01-13

8.  Mechanism of membrane damage by El Tor hemolysin of Vibrio cholerae O1.

Authors:  H Ikigai; A Akatsuka; H Tsujiyama; T Nakae; T Shimamura
Journal:  Infect Immun       Date:  1996-08       Impact factor: 3.441

9.  Role of the stereochemistry of the hydroxyl group of cholesterol and the formation of nonbilayer structures in phosphatidylethanolamines.

Authors:  J J Cheetham; E Wachtel; D Bach; R M Epand
Journal:  Biochemistry       Date:  1989-10-31       Impact factor: 3.162

10.  Identification of signal peptide peptidase, a presenilin-type aspartic protease.

Authors:  Andreas Weihofen; Kathleen Binns; Marius K Lemberg; Keith Ashman; Bruno Martoglio
Journal:  Science       Date:  2002-06-21       Impact factor: 47.728
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  30 in total

1.  Stereospecific requirement of cholesterol in the function of the serotonin1A receptor.

Authors:  Md Jafurulla; Bhagyashree D Rao; Sugunan Sreedevi; Jean-Marie Ruysschaert; Douglas F Covey; Amitabha Chattopadhyay
Journal:  Biochim Biophys Acta       Date:  2013-09-02

2.  Chiral twist drives raft formation and organization in membranes composed of rod-like particles.

Authors:  Louis Kang; Tom C Lubensky
Journal:  Proc Natl Acad Sci U S A       Date:  2016-12-20       Impact factor: 11.205

3.  Investigating the allosterism of acyl-CoA:cholesterol acyltransferase (ACAT) by using various sterols: in vitro and intact cell studies.

Authors:  Jay Liu; Catherine C Y Chang; Emily J Westover; Douglas F Covey; Ta-Yuan Chang
Journal:  Biochem J       Date:  2005-10-15       Impact factor: 3.857

4.  Relationship between phosphatidylinositol 4-phosphate synthesis, membrane organization, and lateral diffusion of PI4KIIalpha at the trans-Golgi network.

Authors:  Shane Minogue; K M Emily Chu; Emily J Westover; Douglas F Covey; J Justin Hsuan; Mark G Waugh
Journal:  J Lipid Res       Date:  2010-04-13       Impact factor: 5.922

5.  Oxysterols as non-genomic regulators of cholesterol homeostasis.

Authors:  Agata A Bielska; Paul Schlesinger; Douglas F Covey; Daniel S Ory
Journal:  Trends Endocrinol Metab       Date:  2012-01-11       Impact factor: 12.015

6.  Comparison of effects of U18666A and enantiomeric U18666A on sterol synthesis and induction of apoptosis.

Authors:  Richard J Cenedella; Patricia S Sexton; Kathiresan Krishnan; Douglas F Covey
Journal:  Lipids       Date:  2005-06       Impact factor: 1.880

7.  Role of chirality in peptide-induced formation of cholesterol-rich domains.

Authors:  Richard M Epand; Scott D Rychnovsky; Jitendra D Belani; Raquel F Epand
Journal:  Biochem J       Date:  2005-09-01       Impact factor: 3.857

8.  Side chain oxygenated cholesterol regulates cellular cholesterol homeostasis through direct sterol-membrane interactions.

Authors:  Sarah E Gale; Emily J Westover; Nicole Dudley; Kathiresan Krishnan; Sean Merlin; David E Scherrer; Xianlin Han; Xiuhong Zhai; Howard L Brockman; Rhoderick E Brown; Douglas F Covey; Jean E Schaffer; Paul Schlesinger; Daniel S Ory
Journal:  J Biol Chem       Date:  2008-11-06       Impact factor: 5.157

9.  Distinct mechanisms underlying cholesterol protection against alcohol-induced BK channel inhibition and resulting vasoconstriction.

Authors:  Shivantika Bisen; Olga Seleverstov; Jitendra Belani; Scott Rychnovsky; Alex M Dopico; Anna N Bukiya
Journal:  Biochim Biophys Acta       Date:  2016-08-24

10.  Cholesterol effects on BAX pore activation.

Authors:  Eric Christenson; Sean Merlin; Mitsu Saito; Paul Schlesinger
Journal:  J Mol Biol       Date:  2008-06-20       Impact factor: 5.469
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