Literature DB >> 15700067

Inversion of enantioselectivity of asymmetric biocatalytic decarboxylation by site-directed mutagenesis based on the reaction mechanism.

Yoichiro Ijima1, Kaori Matoishi, Yosuke Terao, Nobuhide Doi, Hiroshi Yanagawa, Hiromichi Ohta.   

Abstract

The introduction of two mutations (G74C/C188S) based on the estimated reaction mechanism resulted in the inversion of enantioselectivity of arylmalonate decarboxylase, which catalyses the asymmetric decarboxylation of arylmethylmalonate to give optically active arylpropionate.

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Year:  2005        PMID： 15700067     DOI： 10.1039/b416398b

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  10 in total

Review 1.  Enantioselective protonation.

Authors:  Justin T Mohr; Allen Y Hong; Brian M Stoltz
Journal:  Nat Chem       Date:  2009-08       Impact factor: 24.427

2.  Crystallization and preliminary X-ray diffraction experiments of arylmalonate decarboxylase from Alcaligenes bronchisepticus.

Authors:  Masayoshi Nakasako; Rika Obata; Ryosuke Okubo; Shyuichi Nakayama; Kenji Miyamoto; Hiromichi Ohta
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2008-06-11

Review 3.  Analyzing protein structure and function using ancestral gene reconstruction.

Authors:  Michael J Harms; Joseph W Thornton
Journal:  Curr Opin Struct Biol       Date:  2010-04-21       Impact factor: 6.809

Review 4.  Enzyme (re)design: lessons from natural evolution and computation.

Authors:  John A Gerlt; Patricia C Babbitt
Journal:  Curr Opin Chem Biol       Date:  2009-02-23       Impact factor: 8.822

5.  How a single-point mutation in horseradish peroxidase markedly enhances enantioselectivity.

Authors:  Eugene Antipov; Art E Cho; Alexander M Klibanov
Journal:  J Am Chem Soc       Date:  2009-08-12       Impact factor: 15.419

6.  Improvement of the Process Stability of Arylmalonate Decarboxylase by Immobilization for Biocatalytic Profen Synthesis.

Authors:  Miriam Aßmann; Carolin Mügge; Sarah Katharina Gaßmeyer; Junichi Enoki; Lutz Hilterhaus; Robert Kourist; Andreas Liese; Selin Kara
Journal:  Front Microbiol       Date:  2017-03-16       Impact factor: 5.640

Review 7.  Computational tools for the evaluation of laboratory-engineered biocatalysts.

Authors:  Adrian Romero-Rivera; Marc Garcia-Borràs; Sílvia Osuna
Journal:  Chem Commun (Camb)       Date:  2016-12-22       Impact factor: 6.222

8.  Ground-State Destabilization by Active-Site Hydrophobicity Controls the Selectivity of a Cofactor-Free Decarboxylase.

Authors:  Michal Biler; Rory M Crean; Anna K Schweiger; Robert Kourist; Shina Caroline Lynn Kamerlin
Journal:  J Am Chem Soc       Date:  2020-11-12       Impact factor: 15.419

9.  Sequence-Based Screening for Rare Enzymes: New Insights into the World of AMDases Reveal a Conserved Motif and 58 Novel Enzymes Clustering in Eight Distinct Families.

Authors:  Janine Maimanakos; Jennifer Chow; Sarah K Gaßmeyer; Simon Güllert; Florian Busch; Robert Kourist; Wolfgang R Streit
Journal:  Front Microbiol       Date:  2016-08-25       Impact factor: 5.640

10.  Chemoenzymatic Cascade Synthesis of Optically Pure Alkanoic Acids by Using Engineered Arylmalonate Decarboxylase Variants.

Authors:  Junichi Enoki; Carolin Mügge; Dirk Tischler; Kenji Miyamoto; Robert Kourist
Journal:  Chemistry       Date:  2019-03-12       Impact factor: 5.236
  10 in total

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