| Literature DB >> 15696376 |
Naoko Iwasaki1, Yukio Horikawa2, Takafumi Tsuchiya3, Yutaka Kitamura4, Takahiro Nakamura4, Yukio Tanizawa5, Yoshitomo Oka6, Kazuo Hara7, Takashi Kadowaki7, Takuya Awata8, Masashi Honda9, Katsuko Yamashita10, Naohisa Oda11, Li Yu2, Norihiro Yamada2, Makiko Ogata12, Naoyuki Kamatani4, Yasuhiko Iwamoto12, Laura Del Bosque-Plata3, M Geoffrey Hayes3, Nancy J Cox3, Graeme I Bell3.
Abstract
Variation in the gene encoding the cysteine protease calpain-10 has been linked and associated with risk of type 2 diabetes. We have examined the effect of three polymorphisms in the calpain-10 gene (SNP-43, Indel-19, and SNP-63) on the development of type 2 diabetes in the Japanese population in a pooled analysis of 927 patients and 929 controls. We observed that SNP-43, Indel-19, and SNP-63 either individually or as a haplotype were not associated with altered risk of type 2 diabetes with the exception of the rare 111/221 haplogenotype (odds ratio (OR) =3.53, P=0.02). However, stratification based on the median age-at-diagnosis in the pooled study population (<50 and > or =50 years) revealed that allele 2 of Indel-19 and the 121 haplotype were associated with reduced risk in patients with later age-at-diagnosis (age-at-diagnosis > or =50 years OR=0.82 and 0.80, respectively; P=0.04 and 0.02). Thus, variation in the calpain-10 gene may affect risk of type 2 diabetes in Japanese, especially in older individuals.Entities:
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Year: 2005 PMID： 15696376 DOI： 10.1007/s10038-004-0225-5
Source DB: PubMed Journal: J Hum Genet ISSN： 1434-5161 Impact factor: 3.172