Literature DB >> 15695098

Kinesin: walking, crawling or sliding along?

Ahmet Yildiz1, Paul R Selvin.   

Abstract

Kinesins are microtubule-based motor proteins that are involved in cargo transport and mitosis. They are called "motors" because they convert chemical energy to mechanical energy (i.e. force and motion). They use the energy of ATP hydrolysis for their enzymatic processes by walking on microtubules. However, the mechanism underlying their motion has been unclear. Recently, conventional kinesin, which was the first-identified member of the family, has been shown to walk by swapping its two heads in a "hand-over-hand" mechanism. There is also experimental evidence supporting an asymmetric walking of kinesin in which two identical heads of the motor take alternate slow and fast steps. Other cargo-carrier and mitotic kinesins remain uninvestigated and are of great interest to biophysicists.

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Year:  2005        PMID: 15695098     DOI: 10.1016/j.tcb.2004.12.007

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN: 0962-8924            Impact factor:   20.808


  20 in total

Review 1.  Unconventional functions of microtubule motors.

Authors:  Virgil Muresan; Zoia Muresan
Journal:  Arch Biochem Biophys       Date:  2012-01-28       Impact factor: 4.013

Review 2.  Artificial Molecular Machines.

Authors:  Sundus Erbas-Cakmak; David A Leigh; Charlie T McTernan; Alina L Nussbaumer
Journal:  Chem Rev       Date:  2015-09-08       Impact factor: 60.622

Review 3.  Interaction of kinesin motors, microtubules, and MAPs.

Authors:  A Marx; J Müller; E-M Mandelkow; A Hoenger; E Mandelkow
Journal:  J Muscle Res Cell Motil       Date:  2005-12-17       Impact factor: 2.698

Review 4.  To step or not to step? How biochemistry and mechanics influence processivity in Kinesin and Eg5.

Authors:  Megan T Valentine; Susan P Gilbert
Journal:  Curr Opin Cell Biol       Date:  2006-12-26       Impact factor: 8.382

5.  On the hand-over-hand mechanism of kinesin.

Authors:  Qiang Shao; Yi Qin Gao
Journal:  Proc Natl Acad Sci U S A       Date:  2006-05-12       Impact factor: 11.205

6.  Two distinct modes of processive kinesin movement in mixtures of ATP and AMP-PNP.

Authors:  Radhika Subramanian; Jeff Gelles
Journal:  J Gen Physiol       Date:  2007-11       Impact factor: 4.086

7.  Obstacles on the microtubule reduce the processivity of Kinesin-1 in a minimal in vitro system and in cell extract.

Authors:  Ivo A Telley; Peter Bieling; Thomas Surrey
Journal:  Biophys J       Date:  2009-04-22       Impact factor: 4.033

8.  Fission yeast kinesin-8 Klp5 and Klp6 are interdependent for mitotic nuclear retention and required for proper microtubule dynamics.

Authors:  Amy Unsworth; Hirohisa Masuda; Susheela Dhut; Takashi Toda
Journal:  Mol Biol Cell       Date:  2008-09-17       Impact factor: 4.138

9.  Direct measurements of kinesin torsional properties reveal flexible domains and occasional stalk reversals during stepping.

Authors:  Braulio Gutiérrez-Medina; Adrian N Fehr; Steven M Block
Journal:  Proc Natl Acad Sci U S A       Date:  2009-09-23       Impact factor: 11.205

10.  Opposite-polarity motors activate one another to trigger cargo transport in live cells.

Authors:  Shabeen Ally; Adam G Larson; Kari Barlan; Sarah E Rice; Vladimir I Gelfand
Journal:  J Cell Biol       Date:  2009-12-28       Impact factor: 10.539

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