Literature DB >> 15694662

Hypermethylation in promoter region of retinoic acid receptor-beta gene and immunohistochemical findings on retinoic acid receptors in carcinogenesis of endometrium.

Rong Li1, Tsuyoshi Saito, Ryoichi Tanaka, Seiro Satohisa, Katsuya Adachi, Miyabi Horie, Yushi Akashi, Ryuichi Kudo.   

Abstract

In the present study, we analyzed the immunohistochemical findings for the RA receptor (RAR), retinoic X receptor (RXR) and hypermethylation of promoter-region CpG island methylation of RAR-beta2. Immunohistochemistry indicated that though RXR-alpha and -gamma were present in endometrial hyperplasia and cancer, other retinoid receptors were only weakly detected. The hypermethylation of RAR-beta2 was found in 75.0% of endometrial hyperplasia samples and 92.2% of carcinomas. No normal endometria had methylation. This evidence may point to one of the reasons why endometrial hyperplasia acquires high proliferative capacity without differentiation, and the hypermethylation of RAR-beta2 may occur in the early stage of endometrial carcinogenesis.

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Year:  2005        PMID： 15694662     DOI： 10.1016/j.canlet.2004.06.044

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  13 in total

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Authors:  Megumi Yanokura; Kouji Banno; Yusuke Kobayashi; Hiroyuki Nomura; Shigenori Hayashi; Eiichiro Tominaga; Daisuke Aoki
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3.  Promoter hypermethylation of CIDEA, HAAO and RXFP3 associated with microsatellite instability in endometrial carcinomas.

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Journal:  Gynecol Oncol       Date:  2010-03-07       Impact factor: 5.482

Review 4.  DNA methylation in endometrial cancer.

Authors:  Meng Hua Tao; Jo L Freudenheim
Journal:  Epigenetics       Date:  2010-08-16       Impact factor: 4.528

5.  Retinoid acid receptors in human colorectal cancer: An unexpected link with patient outcome.

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Journal:  Mol Cancer       Date:  2010-04-28       Impact factor: 27.401

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Journal:  Virchows Arch       Date:  2013-05-04       Impact factor: 4.064

9.  CTCF genetic alterations in endometrial carcinoma are pro-tumorigenic.

Authors:  A D Marshall; C G Bailey; K Champ; M Vellozzi; P O'Young; C Metierre; Y Feng; A Thoeng; A M Richards; U Schmitz; M Biro; R Jayasinghe; L Ding; L Anderson; E R Mardis; J E J Rasko
Journal:  Oncogene       Date:  2017-03-20       Impact factor: 9.867

10.  Gene expression analysis of early stage endometrial cancers reveals unique transcripts associated with grade and histology but not depth of invasion.

Authors:  John I Risinger; Jay Allard; Uma Chandran; Roger Day; Gadisetti V R Chandramouli; Caela Miller; Christopher Zahn; Julie Oliver; Tracy Litzi; Charlotte Marcus; Elizabeth Dubil; Kevin Byrd; Yovanni Cassablanca; Michael Becich; Andrew Berchuck; Kathleen M Darcy; Chad A Hamilton; Thomas P Conrads; G Larry Maxwell
Journal:  Front Oncol       Date:  2013-06-17       Impact factor: 6.244
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