| Literature DB >> 15694658 |
Perumal Panneerselvam1, Rajasree R Nair, Gudaparthi Vijayalakshmi, Ekambaram Harihara Subramanian, Seshaiah Krishnan Sridhar.
Abstract
In the present study, a novel series of Schiff bases of 4-(4-aminophenyl)-morpholine were synthesised and characterised by IR, 1H-NMR, 13C-NMR, Mass spectral and elemental analysis. The compounds were screened for antibacterial (Staphylococcus aureus (ATCC 9144), Staphylococcus epidermidis (ATCC 155), Bacillus cereus (ATCC 11778), Micrococcus luteus (ATCC 4678), and Escherichia coli (ATCC 25922)) and antifungal (Candida albicans (ATCC 2091) and Aspergillus niger (ATCC 9029)) activities. The minimum inhibitory concentrations of the compounds were also ascertained by agar streak dilution method. 4-(4-(4-Hydroxy-benzylidene-imino)phenyl)-morpholine (7) was found to be the most potent antimicrobial activity with MIC of 25, 19, 21, 16, 29, 20 and 40 microg/ml against S. aureus, S. epidermidis, B. cereus, M. luteus, E. coli, C. albicans and A. niger, respectively. All the other compounds exhibited moderate activity against the bacterial and fungal organisms tested.Entities:
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Year: 2005 PMID： 15694658 DOI： 10.1016/j.ejmech.2004.09.003
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514