| Literature DB >> 15694262 |
Wei Qin1, Jianjun Gao, Qinghe Xing, Jiandong Yang, Xueqing Qian, Xingwang Li, Zhongmeng Guo, Helong Chen, Lijun Wang, Xuanyin Huang, Niufan Gu, Guoyin Feng, Lin He.
Abstract
Recently, proteolipid protein 1 (PLP1) has been identified as downregulated in schizophrenia by quantitative PCR and other technologies. In this work we attempted to investigate the role of PLP1 in the etiology of schizophrenia using a family based association study in 487 Chinese Han family trios. The TDT for allelic association demonstrated that, in male, a weak association was detected in SNP rs475827 with p=0.0294, suggesting that the genetic polymorphisms within PLP1 in male are likely to confer an increased susceptibility to schizophrenia in the Chinese population.Entities:
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Year: 2004 PMID： 15694262 DOI： 10.1016/j.neulet.2004.11.013
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046