| Literature DB >> 18604471 |
Branko Aleksic1,2,3, Masashi Ikeda4,5, Ryoko Ishihara6,5, Shinichi Saito6,5, Toshiya Inada7, Nakao Iwata4,5, Norio Ozaki6,5.
Abstract
PLP1 is one of the major myelin-related genes. A large body of expression-based studies showed significantly lower levels of the PLP1 messenger ribonucleic acid (mRNA) transcripts in schizophrenia. Moreover, one family-based study identified a weak association signal in a male subset using 487 Chinese family trios. We carried out a population-based association study between PLP1 and schizophrenia in 1,640 subjects. Our data does not support genetic variation in close vicinity or within PLP1 locus as a susceptibility factor.Entities:
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Year: 2008 PMID： 18604471 DOI： 10.1007/s10038-008-0318-7
Source DB: PubMed Journal: J Hum Genet ISSN： 1434-5161 Impact factor: 3.172