| Literature DB >> 15686936 |
Yongxin Han1, André Giroux, John Colucci, Christopher I Bayly, Daniel J Mckay, Sophie Roy, Steve Xanthoudakis, John Vaillancourt, Dita M Rasper, John Tam, Paul Tawa, Donald W Nicholson, Robert J Zamboni.
Abstract
The iterative process for the discovery of a series of pyrazinone mono-amides as potent, selective and reversible non-peptide caspase-3 inhibitors (e.g., M826 and M867) is reported. These compounds display potent anti apoptotic activities in a number of cell based systems in vitro as well as in several animal models in vivo.Entities:
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Year: 2005 PMID： 15686936 DOI： 10.1016/j.bmcl.2004.12.006
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823