Literature DB >> 15686921

Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13).

Soong-Hoon Kim1, Andrew T Pudzianowski, Kenneth J Leavitt, Joseph Barbosa, Patricia A McDonnell, William J Metzler, Bruce M Rankin, Richard Liu, Wayne Vaccaro, William Pitts.   

Abstract

Computer aided drug design led to a new class of spiro-barbiturates (e.g., 4a, MMP-13 K(i)=4.7 nM) that are potent inhibitors of MMP-13.

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Year:  2005        PMID： 15686921     DOI： 10.1016/j.bmcl.2004.12.016

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

Review 1.  Matrix metalloproteinase inhibitors as investigative tools in the pathogenesis and management of vascular disease.

Authors:  Mina M Benjamin; Raouf A Khalil
Journal:  Exp Suppl       Date:  2012

2.  Synthesis of barbiturate-based methionine aminopeptidase-1 inhibitors.

Authors:  Manas K Haldar; Michael D Scott; Nitesh Sule; D K Srivastava; Sanku Mallik
Journal:  Bioorg Med Chem Lett       Date:  2008-03-04       Impact factor: 2.823

Review 3.  Matrix Metalloproteinase Inhibitors as Investigational and Therapeutic Tools in Unrestrained Tissue Remodeling and Pathological Disorders.

Authors:  Jie Liu; Raouf A Khalil
Journal:  Prog Mol Biol Transl Sci       Date:  2017-05-10       Impact factor: 3.622

Review 4.  Matrix metalloproteinases as potential targets in the venous dilation associated with varicose veins.

Authors:  Arda Kucukguven; Raouf A Khalil
Journal:  Curr Drug Targets       Date:  2013-03       Impact factor: 3.465

5.  Cheminformatics-based drug design approach for identification of inhibitors targeting the characteristic residues of MMP-13 hemopexin domain.

Authors:  Roopa Kothapalli; Asif M Khan; Anupriya Gopalsamy; Yap Seng Chong; Loganath Annamalai
Journal:  PLoS One       Date:  2010-08-31       Impact factor: 3.240

Review 6.  Role of matrix metalloproteinases and therapeutic benefits of their inhibition in spinal cord injury.

Authors:  Haoqian Zhang; Mayland Chang; Christopher N Hansen; D Michele Basso; Linda J Noble-Haeusslein
Journal:  Neurotherapeutics       Date:  2011-04       Impact factor: 7.620

7.  Antibacterial, antiurease, and antioxidant activities of some arylidene barbiturates.

Authors:  Bahar Bilgin Sokmen; Serpil Ugras; Hasan Yucel Sarikaya; Halil Ibrahim Ugras; Refiye Yanardag
Journal:  Appl Biochem Biotechnol       Date:  2013-09-11       Impact factor: 2.926

8.  A novel substrate directed multicomponent reaction for the syntheses of tetrahydro-spiro[pyrazolo[4,3-f]quinoline]-8,5'-pyrimidines and tetrahydro-pyrazolo[4,3-f]pyrimido[4,5-b]quinolines via selective multiple C-C bond formation under metal-free conditions.

Authors:  Divyang M Patel; Hetal J Patel; José M Padrón; Hitendra M Patel
Journal:  RSC Adv       Date:  2020-05-22       Impact factor: 4.036

9.  Green Synthesis and Urease Inhibitory Activity of Spiro-Pyrimidinethiones/Spiro-Pyrimidinones-Barbituric Acid Derivatives.

Authors:  Ghodsi Mohammadi Ziarani; Shima Asadi; Sakineh Faramarzi; Massoud Amanlou
Journal:  Iran J Pharm Res       Date:  2015       Impact factor: 1.696

10.  Bifunctional thiourea-catalyzed asymmetric [3 + 2] annulation reactions of 2-isothiocyanato-1-indanones with barbiturate-based olefins.

Authors:  Jiang-Song Zhai; Da-Ming Du
Journal:  Beilstein J Org Chem       Date:  2022-01-04       Impact factor: 2.883
  10 in total

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