Literature DB >> 15686364

Rational design of platinum(IV) compounds to overcome glutathione-S-transferase mediated drug resistance.

Wee Han Ang1, Isam Khalaila, Claire S Allardyce, Lucienne Juillerat-Jeanneret, Paul J Dyson.   

Abstract

A rationally designed Pt(IV) anticancer compound is described, employing the novel concept of tethering an inhibitor of glutathione-S-transferase, an enzyme associated with Pt-based drug-resistance, to cisplatin. Its enzyme inhibition activity, investigated using spectrophotometric and mass spectrometry-based techniques, and cytotoxic profile in resistant cancer cells are described.

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Year:  2005        PMID： 15686364     DOI： 10.1021/ja0432618

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  35 in total

1.  Organoruthenium(II) Complexes Bearing an Aromatase Inhibitor: Synthesis, Characterization, in Vitro Biological Activity and in Vivo Toxicity in Zebrafish Embryos.

Authors:  Golara Golbaghi; Mohammad Mehdi Haghdoost; Debbie Yancu; Yossef López de Los Santos; Nicolas Doucet; Shunmoogum A Patten; J Thomas Sanderson; Annie Castonguay
Journal:  Organometallics       Date:  2019-01-31       Impact factor: 3.876

Review 2.  Redox activation of metal-based prodrugs as a strategy for drug delivery.

Authors:  Nora Graf; Stephen J Lippard
Journal:  Adv Drug Deliv Rev       Date:  2012-01-25       Impact factor: 15.470

Review 3.  Novel metals and metal complexes as platforms for cancer therapy.

Authors:  Michael Frezza; Sarmad Hindo; Di Chen; Andrew Davenport; Sara Schmitt; Dajena Tomco; Q Ping Dou
Journal:  Curr Pharm Des       Date:  2010-06       Impact factor: 3.116

Review 4.  Synthetic methods for the preparation of platinum anticancer complexes.

Authors:  Justin J Wilson; Stephen J Lippard
Journal:  Chem Rev       Date:  2013-11-27       Impact factor: 60.622

5.  Synthesis, characterization, and cytotoxicity of platinum(IV) carbamate complexes.

Authors:  Justin J Wilson; Stephen J Lippard
Journal:  Inorg Chem       Date:  2011-03-01       Impact factor: 5.165

6.  Diamminetetrakis(carboxylato)platinum(IV) complexes--synthesis, characterization, and cytotoxicity.

Authors:  Björn R Hoffmeister; Mahsa S Adib-Razavi; Michael A Jakupec; Markus Galanski; Bernhard K Keppler
Journal:  Chem Biodivers       Date:  2012-09       Impact factor: 2.408

7.  Conjugates of cisplatin and cyclooxygenase inhibitors as potent antitumor agents overcoming cisplatin resistance.

Authors:  Wilma Neumann; Brenda C Crews; Lawrence J Marnett; Evamarie Hey-Hawkins
Journal:  ChemMedChem       Date:  2014-05-06       Impact factor: 3.466

8.  Identification of the molecular mechanisms underlying the cytotoxic action of a potent platinum metallointercalator.

Authors:  Shaoyu Wang; Vincent J Higgins; Janice R Aldrich-Wright; Ming J Wu
Journal:  J Chem Biol       Date:  2011-12-06

9.  In vitro cytotoxic activity of tri-n-butyltin(IV)lupinylsulfide hydrogen fumarate (IST-FS 35) and preliminary antitumor activity in vivo.

Authors:  Angela Alama; Maurizio Viale; Michele Cilli; Cristina Bruzzo; Federica Novelli; Bruno Tasso; Fabio Sparatore
Journal:  Invest New Drugs       Date:  2008-06-19       Impact factor: 3.850

Review 10.  The Platin-X series: activation, targeting, and delivery.

Authors:  Uttara Basu; Bhabatosh Banik; Ru Wen; Rakesh K Pathak; Shanta Dhar
Journal:  Dalton Trans       Date:  2016-08-16       Impact factor: 4.390
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