Literature DB >> 22976974

Diamminetetrakis(carboxylato)platinum(IV) complexes--synthesis, characterization, and cytotoxicity.

Björn R Hoffmeister1, Mahsa S Adib-Razavi, Michael A Jakupec, Markus Galanski, Bernhard K Keppler.   

Abstract

A series of eight novel diamminetetrakis(carboxylato)platinum(IV) complexes was synthesized and characterized by multinuclear (1)H-, (13)C-, (15)N-, and (195)Pt-NMR spectroscopy. Their antiproliferative potency was evaluated in three human cancer cell lines representing ovarian (CH1), lung (A549), and colon carcinoma (SW480). In cisplatin-sensitive CH1 cancer cells, cytotoxicity was found in the low micromolar range, whereas, in inherently cisplatin-resistant A549 and SW480 cells, the activity was very low or negligible. Astonishingly, raise in lipophilicity of the complexes, as found in the case of cisplatin analogs, did not result in a significant enhancement of the cytotoxic effect.
Copyright © 2012 Verlag Helvetica Chimica Acta AG, Zürich.

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Year:  2012        PMID： 22976974      PMCID： PMC3499686          DOI： 10.1002/cbdv.201200019

Source DB:  PubMed          Journal:  Chem Biodivers        ISSN： 1612-1872            Impact factor:   2.408


  27 in total

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Authors:  Michael R Reithofer; Anna K Bytzek; Seied M Valiahdi; Christian R Kowol; Michael Groessl; Christian G Hartinger; Michael A Jakupec; Markus Galanski; Bernhard K Keppler
Journal:  J Inorg Biochem       Date:  2010-10-01       Impact factor: 4.155

2.  Soluble single-walled carbon nanotubes as longboat delivery systems for platinum(IV) anticancer drug design.

Authors:  Rodney P Feazell; Nozomi Nakayama-Ratchford; Hongjie Dai; Stephen J Lippard
Journal:  J Am Chem Soc       Date:  2007-06-15       Impact factor: 15.419

3.  Carboxylation of Kinetically Inert Platinum(IV) Hydroxy Complexes. An Entr.acte.ee into Orally Active Platinum(IV) Antitumor Agents.

Authors:  C M Giandomenico; M J Abrams; B A Murrer; J F Vollano; M I Rheinheimer; S B Wyer; G E Bossard; J D Higgins
Journal:  Inorg Chem       Date:  1995-03       Impact factor: 5.165

4.  Mitaplatin, a potent fusion of cisplatin and the orphan drug dichloroacetate.

Authors:  Shanta Dhar; Stephen J Lippard
Journal:  Proc Natl Acad Sci U S A       Date:  2009-12-10       Impact factor: 11.205

5.  Polyvalent oligonucleotide gold nanoparticle conjugates as delivery vehicles for platinum(IV) warheads.

Authors:  Shanta Dhar; Weston L Daniel; David A Giljohann; Chad A Mirkin; Stephen J Lippard
Journal:  J Am Chem Soc       Date:  2009-10-21       Impact factor: 15.419

6.  Conjugated platinum(IV)-peptide complexes for targeting angiogenic tumor vasculature.

Authors:  Sumitra Mukhopadhyay; Carmen M Barnés; Ariel Haskel; Sarah M Short; Katie R Barnes; Stephen J Lippard
Journal:  Bioconjug Chem       Date:  2007-09-11       Impact factor: 4.774

7.  Mono-carboxylated diaminedichloridoplatinum(IV) complexes--selective synthesis, characterization, and cytotoxicity.

Authors:  Verena Pichler; Seied M Valiahdi; Michael A Jakupec; Vladimir B Arion; Mathea S Galanski; Bernhard K Keppler
Journal:  Dalton Trans       Date:  2011-07-11       Impact factor: 4.569

8.  Synthesis and characterization of novel bis(carboxylato)dichloridobis(ethylamine)platinum(IV) complexes with higher cytotoxicity than cisplatin.

Authors:  Hristo Varbanov; Seied M Valiahdi; Anton A Legin; Michael A Jakupec; Alexander Roller; Mathea S. Galanski; Bernhard K Keppler
Journal:  Eur J Med Chem       Date:  2011-09-08       Impact factor: 7.088

9.  Novel di- and tetracarboxylatoplatinum(IV) complexes. Synthesis, characterization, cytotoxic activity, and DNA platination.

Authors:  Michael R Reithofer; Seied M Valiahdi; Michael A Jakupec; Vladimir B Arion; Alexander Egger; Mathea Sophia Galanski; Bernhard K Keppler
Journal:  J Med Chem       Date:  2007-11-22       Impact factor: 7.446

10.  Novel endothall-containing platinum(IV) complexes: synthesis, characterization, and cytotoxic activity.

Authors:  Michael R Reithofer; Seied M Valiahdi; Markus Galanski; Michael A Jakupec; Vladimir B Arion; Bernhard K Keppler
Journal:  Chem Biodivers       Date:  2008-10       Impact factor: 2.745
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  3 in total

Review 1.  Synthetic methods for the preparation of platinum anticancer complexes.

Authors:  Justin J Wilson; Stephen J Lippard
Journal:  Chem Rev       Date:  2013-11-27       Impact factor: 60.622

2.  Comparative in vitro and in vivo pharmacological investigation of platinum(IV) complexes as novel anticancer drug candidates for oral application.

Authors:  Sarah Theiner; Hristo P Varbanov; Markus Galanski; Alexander E Egger; Walter Berger; Petra Heffeter; Bernhard K Keppler
Journal:  J Biol Inorg Chem       Date:  2014-11-21       Impact factor: 3.358

3.  A novel class of bis- and tris-chelate diam(m)inebis(dicarboxylato)platinum(IV) complexes as potential anticancer prodrugs.

Authors:  Hristo P Varbanov; Simone Göschl; Petra Heffeter; Sarah Theiner; Alexander Roller; Frank Jensen; Michael A Jakupec; Walter Berger; Mathea Sophia Galanski; Bernhard K Keppler
Journal:  J Med Chem       Date:  2014-07-30       Impact factor: 7.446
  3 in total

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