Bojan Pajic1, Richard H Greiner. 1. Department of Ophthalmology, Klinik Pallas, Louis-Giroud-Strasse 20, 4600 Olten, Switzerland.
Abstract
BACKGROUND AND PURPOSE: To evaluate long term results and to demonstrate safety and efficacy of non-surgical, exclusive strontium-/yttrium-90 beta irradiation of non-operated pterygia. PATIENTS AND METHODS: Between March 1977 and April 1999, 43 patients with 54 primary pterygia were treated with an exclusive strontium-/yttrium-90 beta-irradiation up to a total dose of 50 Gy divided in four fractions with one week apart. All patients were referred from the same ophthalmologist. The average follow-up were 112(+/-88 months (range, 12-321 months), median 96 months. RESULTS: The patients were referred with early symptomatic manifestations of pterygia with a mean horizontal diameter of 1.6+/-0.7 mm (range, 0.5-4.5 mm), which shrank to a mean diameter of 0.9+/-0.6 mm (range, 0-2.5 mm) after irradiation (P<0.005). There was a reduction of size in every pterygium, none of the 54 pterygia developed a recurrent growth and there were no patient with any late side effect. Following the strontium-/yttrium-90 application the process came up with an obliteration of the vessels, which resulted in a grey, thin and avascular pannus. CONCLUSIONS: Strontium-/yttrium-90 beta-irradiation as an exclusive, non-surgical treatment for early pterygia provides a significant reduction of the size of the irradiated pterygia, is a safe and effective therapy to prevent a recurrence and can be performed without late side effects.
BACKGROUND AND PURPOSE: To evaluate long term results and to demonstrate safety and efficacy of non-surgical, exclusive strontium-/yttrium-90 beta irradiation of non-operated pterygia. PATIENTS AND METHODS: Between March 1977 and April 1999, 43 patients with 54 primary pterygia were treated with an exclusive strontium-/yttrium-90 beta-irradiation up to a total dose of 50 Gy divided in four fractions with one week apart. All patients were referred from the same ophthalmologist. The average follow-up were 112(+/-88 months (range, 12-321 months), median 96 months. RESULTS: The patients were referred with early symptomatic manifestations of pterygia with a mean horizontal diameter of 1.6+/-0.7 mm (range, 0.5-4.5 mm), which shrank to a mean diameter of 0.9+/-0.6 mm (range, 0-2.5 mm) after irradiation (P<0.005). There was a reduction of size in every pterygium, none of the 54 pterygia developed a recurrent growth and there were no patient with any late side effect. Following the strontium-/yttrium-90 application the process came up with an obliteration of the vessels, which resulted in a grey, thin and avascular pannus. CONCLUSIONS:Strontium-/yttrium-90 beta-irradiation as an exclusive, non-surgical treatment for early pterygia provides a significant reduction of the size of the irradiated pterygia, is a safe and effective therapy to prevent a recurrence and can be performed without late side effects.
Authors: Bojan Pajic; Daniel M Aebersold; Andreas Eggspuehler; Frederik R Theler; Harald P Studer Journal: Sensors (Basel) Date: 2017-05-24 Impact factor: 3.576