| Literature DB >> 15682847 |
Takayoshi Ishimori1, Tsuneo Saga, Yasushi Nagata, Yuji Nakamoto, Tatsuya Higashi, Marcelo Mamede, Takahiro Mukai, Yoshiharu Negoro, Tetsuya Aoki, Masahiro Hiraoka, Junji Konishi.
Abstract
This study was performed to investigate the feasibility of FDG- and L-[methyl-11C]methionine (Met)-PET for the follow up of lung cancer after stereotactic radiotherapy (SRT). Nine patients (pt) with solitary lung cancer underwent SRT. Met- and FDG-PET studies were performed one week before SRT and from one week to 8 months after SRT. Responses to SRT were complete in 2 pt and partial in 7 pt. Met- and FDG-PET scan showed high tracer uptake in all tumors before SRT. After SRT, standardized uptake values (SUV) of FDG and Met changed concordantly. Both decreased with time in 5 pt but did not decrease steadily in 4 pt, where 2 pt showed an increase at 1 to 2 weeks after SRT and 2 pt showed an increase at more than 3 months after SRT. The former appears to reflect the acute reaction to SRT and the latter radiation-induced pneumonitis. Although the addition of Met-PET did not provide additional information over FDG-PET, FDG- and Met-PET could be used to evaluate the treatment effect of SRT.Entities:
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Year: 2004 PMID： 15682847 DOI： 10.1007/bf02985960
Source DB: PubMed Journal: Ann Nucl Med ISSN： 0914-7187 Impact factor: 2.668