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Literature DB >> 15680762

One-component systems dominate signal transduction in prokaryotes.

Luke E Ulrich¹, Eugene V Koonin, Igor B Zhulin.

Abstract

Two-component systems that link environmental signals to cellular responses are viewed as the primary mode of signal transduction in prokaryotes. By analyzing information encoded by 145 prokaryotic genomes, we found that the majority of signal transduction systems consist of a single protein that contains input and output domains but lacks phosphotransfer domains typical of two-component systems. One-component systems are evolutionarily older, more widely distributed among bacteria and archaea, and display a greater diversity of domains than two-component systems.

Mesh：

Year: 2005 PMID： 15680762 PMCID： PMC2756188 DOI： 10.1016/j.tim.2004.12.006

Source DB: PubMed Journal: Trends Microbiol ISSN： 0966-842X Impact factor: 17.079

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