| Literature DB >> 15679332 |
Ji Ma1, Shannon H Jones, Sidney M Hecht.
Abstract
A crude CH(2)Cl(2)-MeOH extract prepared from Commiphora africana was found to mediate Cu(2+)-dependent relaxation of supercoiled plasmid DNA. Bioassay-guided fractionation of this extract was carried out and was monitored by the use of an in vitro DNA strand scission assay. The dihydroflavonol glucoside phellamurin (1) was identified as the active principle responsible for the DNA cleavage activity of the crude extract.Entities:
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Year: 2005 PMID： 15679332 DOI： 10.1021/np0400510
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050