Literature DB >> 15677913

A review of activity indices and end points for clinical trials in children with Crohn's disease.

Anne M Griffiths1, Anthony R Otley, Jeffrey Hyams, Antonio R Quiros, Richard J Grand, Athos Bousvaros, Brian G Feagan, George R Ferry.   

Abstract

The necessity to include children and adolescents in clinical trials is increasingly recognized. Two recent workshops provided the impetus for pediatric gastroenterologists to develop evidence-based recommendations concerning end points and outcome assessment in cases of pediatric Crohn's disease. The overall goal was to facilitate clinical trial design by standardizing the methodology. This article critically reviews the available assessment tools and provides consensus recommendations for the evaluation of linear growth, disease activity, and health-related quality of life in clinical trials in pediatric Crohn's disease.

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Year:  2005        PMID： 15677913     DOI： 10.1097/00054725-200502000-00013

Source DB:  PubMed          Journal:  Inflamm Bowel Dis        ISSN： 1078-0998            Impact factor:   5.325


  15 in total

1.  Assessing pediatric ileocolonic Crohn's disease activity based on global MR enterography scores.

Authors:  Fabio Pomerri; Faise Al Bunni; Monica Zuliani; Graziella Guariso; Marco Gasparetto; Benedetta Giorgi; Mara Cananzi; Pier Carlo Muzzio
Journal:  Eur Radiol       Date:  2016-06-08       Impact factor: 5.315

2.  Short pediatric Crohn's disease activity index for quality improvement and observational research.

Authors:  Michael D Kappelman; Wallace V Crandall; Richard B Colletti; Anthony Goudie; Ian H Leibowitz; Lynn Duffy; David E Milov; Sandra C Kim; Bess T Schoen; Ashish S Patel; John Grunow; Evette Larry; Gerry Fairbrother; Peter Margolis
Journal:  Inflamm Bowel Dis       Date:  2010-09-01       Impact factor: 5.325

3.  C-reactive protein and disease activity in children with Crohn's disease.

Authors:  Samantha Tilakaratne; Daniel A Lemberg; Steven T Leach; Andrew S Day
Journal:  Dig Dis Sci       Date:  2010-01       Impact factor: 3.199

4.  Measuring quality of life in pediatric patients with inflammatory bowel disease: psychometric and clinical characteristics.

Authors:  James M Perrin; Karen Kuhlthau; Aziz Chughtai; Diane Romm; Barbara S Kirschner; George D Ferry; Stanley A Cohen; Benjamin D Gold; Melvin B Heyman; Robert N Baldassano; Harland S Winter
Journal:  J Pediatr Gastroenterol Nutr       Date:  2008-02       Impact factor: 2.839

5.  Pediatric Inflammatory Bowel Disease Clinical Innovations Meeting of the Crohn's & Colitis Foundation: Charting the Future of Pediatric IBD.

Authors:  Joseph A Picoraro; Dale Lee; Caren A Heller; Alandra Weaver; Jeffrey S Hyams; Laurie S Conklin; Anthony Otley; David Ziring; Subra Kugathasan; Joel R Rosh; Andrew Mulberg; Lee A Denson; Michael D Kappelman; Andrew B Grossman; Athos Bousvaros; K T Park
Journal:  Inflamm Bowel Dis       Date:  2019-01-01       Impact factor: 5.325

6.  Safety and tolerability of low-dose naltrexone therapy in children with moderate to severe Crohn's disease: a pilot study.

Authors:  Jill P Smith; Douglas Field; Sandra I Bingaman; Robert Evans; David T Mauger
Journal:  J Clin Gastroenterol       Date:  2013-04       Impact factor: 3.062

7.  Non-invasive mapping of the gastrointestinal microbiota identifies children with inflammatory bowel disease.

Authors:  Eliseo Papa; Michael Docktor; Christopher Smillie; Sarah Weber; Sarah P Preheim; Dirk Gevers; Georgia Giannoukos; Dawn Ciulla; Diana Tabbaa; Jay Ingram; David B Schauer; Doyle V Ward; Joshua R Korzenik; Ramnik J Xavier; Athos Bousvaros; Eric J Alm
Journal:  PLoS One       Date:  2012-06-29       Impact factor: 3.240

8.  Development of a core outcome set for clinical trials in childhood asthma: a survey of clinicians, parents, and young people.

Authors:  Ian P Sinha; Ruairi Gallagher; Paula R Williamson; Rosalind L Smyth
Journal:  Trials       Date:  2012-07-02       Impact factor: 2.279

9.  Biologics in paediatric Crohn's disease.

Authors:  Oliver Gouldthorpe; Anthony G Catto-Smith; George Alex
Journal:  Gastroenterol Res Pract       Date:  2011-11-17       Impact factor: 2.260

Review 10.  A systematic review of studies that aim to determine which outcomes to measure in clinical trials in children.

Authors:  Ian Sinha; Leanne Jones; Rosalind L Smyth; Paula R Williamson
Journal:  PLoS Med       Date:  2008-04-29       Impact factor: 11.069
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