Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Organization of the MASP2 locus and its expression profile in mouse and rat.

Literature DB >> 15672593

Organization of the MASP2 locus and its expression profile in mouse and rat.

Cordula M Stover¹, Nicholas J Lynch, Steven J Hanson, Michaela Windbichler, Simon G Gregory, Wilhelm J Schwaeble.

Abstract

The mouse, rat, and human MASP2 loci are situated on syntenic chromosome regions and are highly conserved. They comprise the genes for MASP-2/ MAp19, TAR DNA binding protein of 43 kDa, FRAP kinase, CDT6, Polymyositis-Scleroderma 100-kDa autoantigen, spermidine synthase, and TERE which were analyzed by annotation of available gene transcript data and cross-species comparison of available genomic sequences. The human and rat genes for spermidine synthase have an additional intron compared to the mouse gene. The mouse and rat genes for Polymyositis-Scleroderma 100-kDa autoantigen have an additional exon compared to the human gene. We find support for the hypothesis that the MAp19-specific exon within the MASP2 gene may have originated in a transposable element. Blocks of highly conserved intronic sequences were found in the MASP2 gene and the TARDBP gene. The expression of all genes within the MASP2 locus was analyzed in mouse and rat. The restricted expression of MASP-2 and MAp19 mRNA in liver contrasts with the ubiquitous expression of all neighboring genes studied.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2004 PMID： 15672593 DOI： 10.1007/s00335-004-3006-8

Source DB: PubMed Journal: Mamm Genome ISSN： 0938-8990 Impact factor: 2.957

68 in total

Review 1. Regulation of mRNA stability in mammalian cells.

Authors: J Guhaniyogi; G Brewer
Journal: Gene Date: 2001-03-07 Impact factor: 3.688

2. Mapping of the human spermidine synthase gene (SRM) to 1p36 and a probable pseudogene (SRML2) to region 3p14-->q21.

Authors: R Winqvist; L Alhonen; K H Grzeschik; J Jänne; T O Eloranta
Journal: Cytogenet Cell Genet Date: 1993

Review 3. Conserved structures and diversity of functions of RNA-binding proteins.

Authors: C G Burd; G Dreyfuss
Journal: Science Date: 1994-07-29 Impact factor: 47.728

4. Human spermidine synthase gene: structure and chromosomal localization.

Authors: S Myöhänen; L Kauppinen; J Wahlfors; L Alhonen; J Jänne
Journal: DNA Cell Biol Date: 1991 Jul-Aug Impact factor: 3.311

5. Human and mouse gene structure: comparative analysis and application to exon prediction.

Authors: S Batzoglou; L Pachter; J P Mesirov; B Berger; E S Lander
Journal: Genome Res Date: 2000-07 Impact factor: 9.043

6. Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

Authors: Richard A Gibbs; George M Weinstock; Michael L Metzker; Donna M Muzny; Erica J Sodergren; Steven Scherer; Graham Scott; David Steffen; Kim C Worley; Paula E Burch; Geoffrey Okwuonu; Sandra Hines; Lora Lewis; Christine DeRamo; Oliver Delgado; Shannon Dugan-Rocha; George Miner; Margaret Morgan; Alicia Hawes; Rachel Gill; Robert A Holt; Mark D Adams; Peter G Amanatides; Holly Baden-Tillson; Mary Barnstead; Soo Chin; Cheryl A Evans; Steve Ferriera; Carl Fosler; Anna Glodek; Zhiping Gu; Don Jennings; Cheryl L Kraft; Trixie Nguyen; Cynthia M Pfannkoch; Cynthia Sitter; Granger G Sutton; J Craig Venter; Trevor Woodage; Douglas Smith; Hong-Mei Lee; Erik Gustafson; Patrick Cahill; Arnold Kana; Lynn Doucette-Stamm; Keith Weinstock; Kim Fechtel; Robert B Weiss; Diane M Dunn; Eric D Green; Robert W Blakesley; Gerard G Bouffard; Pieter J De Jong; Kazutoyo Osoegawa; Baoli Zhu; Marco Marra; Jacqueline Schein; Ian Bosdet; Chris Fjell; Steven Jones; Martin Krzywinski; Carrie Mathewson; Asim Siddiqui; Natasja Wye; John McPherson; Shaying Zhao; Claire M Fraser; Jyoti Shetty; Sofiya Shatsman; Keita Geer; Yixin Chen; Sofyia Abramzon; William C Nierman; Paul H Havlak; Rui Chen; K James Durbin; Amy Egan; Yanru Ren; Xing-Zhi Song; Bingshan Li; Yue Liu; Xiang Qin; Simon Cawley; Kim C Worley; A J Cooney; Lisa M D'Souza; Kirt Martin; Jia Qian Wu; Manuel L Gonzalez-Garay; Andrew R Jackson; Kenneth J Kalafus; Michael P McLeod; Aleksandar Milosavljevic; Davinder Virk; Andrei Volkov; David A Wheeler; Zhengdong Zhang; Jeffrey A Bailey; Evan E Eichler; Eray Tuzun; Ewan Birney; Emmanuel Mongin; Abel Ureta-Vidal; Cara Woodwark; Evgeny Zdobnov; Peer Bork; Mikita Suyama; David Torrents; Marina Alexandersson; Barbara J Trask; Janet M Young; Hui Huang; Huajun Wang; Heming Xing; Sue Daniels; Darryl Gietzen; Jeanette Schmidt; Kristian Stevens; Ursula Vitt; Jim Wingrove; Francisco Camara; M Mar Albà; Josep F Abril; Roderic Guigo; Arian Smit; Inna Dubchak; Edward M Rubin; Olivier Couronne; Alexander Poliakov; Norbert Hübner; Detlev Ganten; Claudia Goesele; Oliver Hummel; Thomas Kreitler; Young-Ae Lee; Jan Monti; Herbert Schulz; Heike Zimdahl; Heinz Himmelbauer; Hans Lehrach; Howard J Jacob; Susan Bromberg; Jo Gullings-Handley; Michael I Jensen-Seaman; Anne E Kwitek; Jozef Lazar; Dean Pasko; Peter J Tonellato; Simon Twigger; Chris P Ponting; Jose M Duarte; Stephen Rice; Leo Goodstadt; Scott A Beatson; Richard D Emes; Eitan E Winter; Caleb Webber; Petra Brandt; Gerald Nyakatura; Margaret Adetobi; Francesca Chiaromonte; Laura Elnitski; Pallavi Eswara; Ross C Hardison; Minmei Hou; Diana Kolbe; Kateryna Makova; Webb Miller; Anton Nekrutenko; Cathy Riemer; Scott Schwartz; James Taylor; Shan Yang; Yi Zhang; Klaus Lindpaintner; T Dan Andrews; Mario Caccamo; Michele Clamp; Laura Clarke; Valerie Curwen; Richard Durbin; Eduardo Eyras; Stephen M Searle; Gregory M Cooper; Serafim Batzoglou; Michael Brudno; Arend Sidow; Eric A Stone; J Craig Venter; Bret A Payseur; Guillaume Bourque; Carlos López-Otín; Xose S Puente; Kushal Chakrabarti; Sourav Chatterji; Colin Dewey; Lior Pachter; Nicolas Bray; Von Bing Yap; Anat Caspi; Glenn Tesler; Pavel A Pevzner; David Haussler; Krishna M Roskin; Robert Baertsch; Hiram Clawson; Terrence S Furey; Angie S Hinrichs; Donna Karolchik; William J Kent; Kate R Rosenbloom; Heather Trumbower; Matt Weirauch; David N Cooper; Peter D Stenson; Bin Ma; Michael Brent; Manimozhiyan Arumugam; David Shteynberg; Richard R Copley; Martin S Taylor; Harold Riethman; Uma Mudunuri; Jane Peterson; Mark Guyer; Adam Felsenfeld; Susan Old; Stephen Mockrin; Francis Collins
Journal: Nature Date: 2004-04-01 Impact factor: 49.962

7. TERE1, a novel gene affecting growth regulation in prostate carcinoma.

Authors: Terence W McGarvey; Trang Nguyen; Raghunath Puthiyaveettil; John E Tomaszewski; S Bruce Malkowicz
Journal: Prostate Date: 2003-02-01 Impact factor: 4.104

8. Expression of H-ficolin/Hakata antigen, mannose-binding lectin-associated serine protease (MASP)-1 and MASP-3 by human glioma cell line T98G.

Authors: Mikio Kuraya; Misao Matsushita; Yuichi Endo; Steffen Thiel; Teizo Fujita
Journal: Int Immunol Date: 2003-01 Impact factor: 4.823

9. Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9.

Authors: E Buratti; F E Baralle
Journal: J Biol Chem Date: 2001-07-24 Impact factor: 5.157

Organization of the MASP2 locus and its expression profile in mouse and rat.

Review 1. Regulation of mRNA stability in mammalian cells.

2. Mapping of the human spermidine synthase gene (SRM) to 1p36 and a probable pseudogene (SRML2) to region 3p14-->q21.

Review 3. Conserved structures and diversity of functions of RNA-binding proteins.

4. Human spermidine synthase gene: structure and chromosomal localization.

5. Human and mouse gene structure: comparative analysis and application to exon prediction.

6. Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

7. TERE1, a novel gene affecting growth regulation in prostate carcinoma.

8. Expression of H-ficolin/Hakata antigen, mannose-binding lectin-associated serine protease (MASP)-1 and MASP-3 by human glioma cell line T98G.

9. Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9.

10. A simple dependence between protein evolution rate and the number of protein-protein interactions.

Review 1. Mannan-binding-lectin-associated serine proteases, characteristics and disease associations.

Review 2. Hepatocytes: a key cell type for innate immunity.

3. MAp19, the alternative splice product of the MASP2 gene.

Review 4. TDP-43 Pathology in Alzheimer's Disease.

5. Which pathways trigger the role of complement in ischaemia/reperfusion injury?