BACKGROUND: Recent studies of men with prostate carcinoma suggest that obesity may be associated with more advanced-stage disease and lower overall survival rates. One possible link between body mass index (BMI) and prostate carcinoma prognosis may be disease ascertainment. Prostate-specific antigen (PSA) is widely used to screen for prostate carcinoma. METHODS: The authors examined the association between BMI and PSA in a population-based study of 2779 men without prostate carcinoma. Between 2001 and 2004, these men were enrolled in a study sponsored by the San Antonio Center of Biomarkers of Risk, a clinical and epidemiologic center of the Early Detection Research Network of the National Cancer Institute. RESULTS: The mean PSA value decreased in a linear fashion with an increase in BMI category, from 1.01 ng/mL in normal weight men to 0.69 ng/mL in obese (Class III) men, after adjusting for race/ethnicity and age. CONCLUSIONS: Lower levels of PSA in obese and overweight men could mask biologically consequential prostate carcinoma. 2005 American Cancer Society.
BACKGROUND: Recent studies of men with prostate carcinoma suggest that obesity may be associated with more advanced-stage disease and lower overall survival rates. One possible link between body mass index (BMI) and prostate carcinoma prognosis may be disease ascertainment. Prostate-specific antigen (PSA) is widely used to screen for prostate carcinoma. METHODS: The authors examined the association between BMI and PSA in a population-based study of 2779 men without prostate carcinoma. Between 2001 and 2004, these men were enrolled in a study sponsored by the San Antonio Center of Biomarkers of Risk, a clinical and epidemiologic center of the Early Detection Research Network of the National Cancer Institute. RESULTS: The mean PSA value decreased in a linear fashion with an increase in BMI category, from 1.01 ng/mL in normal weight men to 0.69 ng/mL in obese (Class III) men, after adjusting for race/ethnicity and age. CONCLUSIONS: Lower levels of PSA in obese and overweight men could mask biologically consequential prostate carcinoma. 2005 American Cancer Society.
Authors: Adriana C Vidal; Lauren E Howard; Daniel M Moreira; Ramiro Castro-Santamaria; Gerald L Andriole; Stephen J Freedland Journal: Cancer Epidemiol Biomarkers Prev Date: 2014-09-27 Impact factor: 4.254
Authors: Lionel L Bañez; Simone Albisinni; Stephen J Freedland; Andrea Tubaro; Cosimo De Nunzio Journal: World J Urol Date: 2012-07-31 Impact factor: 4.226
Authors: Stacy Loeb; H Ballentine Carter; Edward M Schaeffer; Luigi Ferrucci; Anna Kettermann; E Jeffrey Metter Journal: J Urol Date: 2009-12 Impact factor: 7.450
Authors: Sarah J Lewis; Ali Murad; Lina Chen; George Davey Smith; Jenny Donovan; Tom Palmer; Freddie Hamdy; David Neal; J Athene Lane; Michael Davis; Angela Cox; Richard M Martin Journal: PLoS One Date: 2010-10-19 Impact factor: 3.240