Literature DB >> 1566869

Arachidonic acid inhibits the secretory K+ channel of cortical collecting duct of rat kidney.

W Wang1, A Cassola, G Giebisch.   

Abstract

We used the patch-clamp technique to study the effects of arachidonic acid (AA) on the 35-pS secretory K+ channel in the apical membrane of rat cortical collecting duct (CCD). Application of 10 microM AA reversibly reduced channel activity to 1% of the control value [sum of open probability (NPo) decreased from 3.8 to 0.04]. AA inhibits the apical 35-pS K+ channel directly, because application of indomethacin (an inhibitor of cyclooxygenase), nordihydroguaiaretic acid (an enzyme inhibitor of lipoxygenase), and clotrimazole (an inhibitor of epoxygenase) failed to antagonize the AA-induced blocking effect on K+ channel activity. Oleic acid, a cis-unsaturated acid, also blocks K+ channel activity. However, the inhibitory constant (Ki) of oleic acid (5.1 microM) is significantly higher than that of AA (2.6 microM). These results indicate that AA and cis-unsaturated fatty acids are involved in downregulating the apical secretory K+ channel of rat CCD.

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Year:  1992        PMID： 1566869     DOI： 10.1152/ajprenal.1992.262.4.F554

Source DB:  PubMed          Journal:  Am J Physiol        ISSN： 0002-9513


  10 in total

Review 1.  Molecular diversity and regulation of renal potassium channels.

Authors:  Steven C Hebert; Gary Desir; Gerhard Giebisch; Wenhui Wang
Journal:  Physiol Rev       Date:  2005-01       Impact factor: 37.312

Review 2.  ATP-sensitive K+ channels in the kidney.

Authors:  U Quast
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1996 Aug-Sep       Impact factor: 3.000

3.  Concentration-dependent modulations of potassium and calcium currents of rat osteoblastic cells by arachidonic acid.

Authors:  D Chesnoy-Marchais; J Fritsch
Journal:  J Membr Biol       Date:  1994-03       Impact factor: 1.843

4.  Inhibition of Ca(2+)-dependent K+ transport and cell dehydration in sickle erythrocytes by clotrimazole and other imidazole derivatives.

Authors:  C Brugnara; L de Franceschi; S L Alper
Journal:  J Clin Invest       Date:  1993-07       Impact factor: 14.808

5.  Epoxyeicosatrienoic acids affect electrolyte transport in renal tubular epithelial cells: dependence on cyclooxygenase and cell polarity.

Authors:  Rolf M Nüsing; Horst Schweer; Ingrid Fleming; Darryl C Zeldin; Markus Wegmann
Journal:  Am J Physiol Renal Physiol       Date:  2007-05-09

Review 6.  A comprehensive guide to the ROMK potassium channel: form and function in health and disease.

Authors:  Paul A Welling; Kevin Ho
Journal:  Am J Physiol Renal Physiol       Date:  2009-05-20

7.  K+ channels in the basolateral membrane of rat cortical collecting duct are regulated by a cGMP-dependent protein kinase.

Authors:  J Hirsch; E Schlatter
Journal:  Pflugers Arch       Date:  1995-01       Impact factor: 3.657

8.  Arachidonic acid inhibits hormone-stimulated cAMP accumulation in the medullary thick ascending limb of the rat kidney by a mechanism sensitive to pertussis toxin.

Authors:  D Firsov; L Aarab; B Mandon; S Siaume-Perez; C de Rouffignac; D Chabardès
Journal:  Pflugers Arch       Date:  1995-03       Impact factor: 3.657

Review 9.  Recent advances in the field of renal potassium excretion: what can we learn from potassium channels?

Authors:  G H Giebisch
Journal:  Yale J Biol Med       Date:  1997 Jul-Aug

10.  Mechanism of apical K+ channel modulation in principal renal tubule cells. Effect of inhibition of basolateral Na(+)-K(+)-ATPase.

Authors:  W H Wang; J Geibel; G Giebisch
Journal:  J Gen Physiol       Date:  1993-05       Impact factor: 4.086
  10 in total

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