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Literature DB >> 19458126

A comprehensive guide to the ROMK potassium channel: form and function in health and disease.

Abstract

The discovery of the renal outer medullary K+ channel (ROMK, K(ir)1.1), the founding member of the inward-rectifying K+ channel (K(ir)) family, by Ho and Hebert in 1993 revolutionized our understanding of potassium channel biology and renal potassium handling. Because of the central role that ROMK plays in the regulation of salt and potassium homeostasis, considerable efforts have been invested in understanding the underlying molecular mechanisms. Here we provide a comprehensive guide to ROMK, spanning from the physiology in the kidney to the organization and regulation by intracellular factors to the structural basis of its function at the atomic level.

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Year: 2009 PMID： 19458126 PMCID： PMC2775575 DOI： 10.1152/ajprenal.00181.2009

Source DB: PubMed Journal: Am J Physiol Renal Physiol ISSN： 1522-1466

176 in total

1. Molecular mechanism of a COOH-terminal gating determinant in the ROMK channel revealed by a Bartter's disease mutation.

Authors: Thomas P Flagg; Dana Yoo; Christopher M Sciortino; Margaret Tate; Michael F Romero; Paul A Welling
Journal: J Physiol Date: 2002-10-15 Impact factor: 5.182

2. The serum and glucocorticoid-inducible kinase SGK1 and the Na+/H+ exchange regulating factor NHERF2 synergize to stimulate the renal outer medullary K+ channel ROMK1.

Authors: C Chris Yun; Monica Palmada; Hamdy M Embark; Olga Fedorenko; Yuxi Feng; Guido Henke; Iwan Setiawan; Christoph Boehmer; Edward J Weinman; Sabrina Sandrasagra; Christoph Korbmacher; Philip Cohen; David Pearce; Florian Lang
Journal: J Am Soc Nephrol Date: 2002-12 Impact factor: 10.121

3. Moving the pH gate of the Kir1.1 inward rectifier channel.

Authors: Mikheil Nanazashvili; Hui Li; Lawrence G Palmer; D Eric Walters; Henry Sackin
Journal: Channels (Austin) Date: 2007 Jan-Feb Impact factor: 2.581

4. Impaired renal NaCl absorption in mice lacking the ROMK potassium channel, a model for type II Bartter's syndrome.

Authors: John N Lorenz; Nancy R Baird; Louise M Judd; William T Noonan; Anastasia Andringa; Thomas Doetschman; Patrice A Manning; Lynne H Liu; Marian L Miller; Gary E Shull
Journal: J Biol Chem Date: 2002-07-16 Impact factor: 5.157

5. Protein kinase C (PKC)-induced phosphorylation of ROMK1 is essential for the surface expression of ROMK1 channels.

Authors: DaoHong Lin; Hyacinth Sterling; Kenneth M Lerea; Gerhard Giebisch; Wen-Hui Wang
Journal: J Biol Chem Date: 2002-09-06 Impact factor: 5.157

Review 6. Mechanism of regulation of renal ion transport by WNK kinases.

Authors: Chou-Long Huang; Sung-Sen Yang; Shih-Hua Lin
Journal: Curr Opin Nephrol Hypertens Date: 2008-09 Impact factor: 2.894

7. Absence of small conductance K+ channel (SK) activity in apical membranes of thick ascending limb and cortical collecting duct in ROMK (Bartter's) knockout mice.

Authors: Ming Lu; Tong Wang; Qingshang Yan; Xinbo Yang; Ke Dong; Mark A Knepper; WenHui Wang; Gerhard Giebisch; Gary E Shull; Steven C Hebert
Journal: J Biol Chem Date: 2002-07-18 Impact factor: 5.157

8. Regulation of ROMK channel and K+ homeostasis by kidney-specific WNK1 kinase.

Authors: Zhen Liu; Hao-Ran Wang; Chou-Long Huang
Journal: J Biol Chem Date: 2009-02-25 Impact factor: 5.157

9. Long-pore electrostatics in inward-rectifier potassium channels.

Authors: Janice L Robertson; Lawrence G Palmer; Benoît Roux
Journal: J Gen Physiol Date: 2008-11-10 Impact factor: 4.086

10. Hydrolyzable ATP and PIP(2) modulate the small-conductance K+ channel in apical membranes of rat cortical-collecting duct (CCD).

Authors: Ming Lu; Steven C Hebert; Gerhard Giebisch
Journal: J Gen Physiol Date: 2002-11 Impact factor: 4.086

78 in total

1. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel.

Authors: Gautam Bhave; Brian A Chauder; Wen Liu; Eric S Dawson; Rishin Kadakia; Thuy T Nguyen; L Michelle Lewis; Jens Meiler; C David Weaver; Lisa M Satlin; Craig W Lindsley; Jerod S Denton
Journal: Mol Pharmacol Date: 2010-10-06 Impact factor: 4.436

2. Hypertension resistance polymorphisms in ROMK (Kir1.1) alter channel function by different mechanisms.

Authors: Liang Fang; Dimin Li; Paul A Welling
Journal: Am J Physiol Renal Physiol Date: 2010-10-06

Review 3. Recent advances in distal tubular potassium handling.

Authors: Aylin R Rodan; Chih-Jen Cheng; Chou-Long Huang
Journal: Am J Physiol Renal Physiol Date: 2011-01-26

Review 4. Multigene kinase network, kidney transport, and salt in essential hypertension.

Authors: Paul A Welling; Yen-Pei C Chang; Eric Delpire; James B Wade
Journal: Kidney Int Date: 2010-04-14 Impact factor: 10.612

5. Inhibitors of the Renal Outer Medullary Potassium Channel.

Authors: Benjamin Blass
Journal: ACS Med Chem Lett Date: 2015-06-19 Impact factor: 4.345

6. Endoplasmic reticulum-associated degradation of the renal potassium channel, ROMK, leads to type II Bartter syndrome.

Authors: Brighid M O'Donnell; Timothy D Mackie; Arohan R Subramanya; Jeffrey L Brodsky
Journal: J Biol Chem Date: 2017-06-19 Impact factor: 5.157

7. The endosomal trafficking factors CORVET and ESCRT suppress plasma membrane residence of the renal outer medullary potassium channel (ROMK).

Authors: Timothy D Mackie; Bo-Young Kim; Arohan R Subramanya; Daniel J Bain; Allyson F O'Donnell; Paul A Welling; Jeffrey L Brodsky
Journal: J Biol Chem Date: 2018-01-08 Impact factor: 5.157