OBJECTIVES: To determine the relationship between mild vascular cognitive impairment (mVCI) and functional disability in older stroke survivors without dementia. DESIGN: Cohort study. SETTING: Stroke patients from representative hospital-based stroke registers. PARTICIPANTS: Three hundred thirty-nine stroke survivors without dementia, aged 75 and older. MEASUREMENTS: Neuropsychological assessments were completed 3 months poststroke. Activities of daily living (ADLs) were evaluated using the Bristol scale. Operationalized criteria, including cognitive impairment no dementia (CIND), were applied for mVCI. RESULTS: Significant impairments of ADLs were evident in mVCI (CIND vs no CIND; basic care: z=3.2; P=.001, intermediate care: z=3.6; P<.001, complex management: z=4.5; P<.001) but varied according to the profile of cognitive impairments. Patients with attentional or global impairments had more severe functional disability than patients with isolated memory deficits, with an intermediate level of dysfunction in patients with executive impairments. CONCLUSION: The findings emphasize the importance of identifying early cognitive impairments to optimize rehabilitation, care planning, and secondary prevention of dementia in stroke patients.
OBJECTIVES: To determine the relationship between mild vascular cognitive impairment (mVCI) and functional disability in older stroke survivors without dementia. DESIGN: Cohort study. SETTING:Strokepatients from representative hospital-based stroke registers. PARTICIPANTS: Three hundred thirty-nine stroke survivors without dementia, aged 75 and older. MEASUREMENTS: Neuropsychological assessments were completed 3 months poststroke. Activities of daily living (ADLs) were evaluated using the Bristol scale. Operationalized criteria, including cognitive impairment no dementia (CIND), were applied for mVCI. RESULTS: Significant impairments of ADLs were evident in mVCI (CIND vs no CIND; basic care: z=3.2; P=.001, intermediate care: z=3.6; P<.001, complex management: z=4.5; P<.001) but varied according to the profile of cognitive impairments. Patients with attentional or global impairments had more severe functional disability than patients with isolated memory deficits, with an intermediate level of dysfunction in patients with executive impairments. CONCLUSION: The findings emphasize the importance of identifying early cognitive impairments to optimize rehabilitation, care planning, and secondary prevention of dementia in strokepatients.
Authors: Kevin R Krull; Gerard Gioia; Kirsten K Ness; Leah Ellenberg; Christopher Recklitis; Wendy Leisenring; Sujuan Huang; Marilyn Stovall; Leslie L Robison; Lonnie Zeltzer Journal: Cancer Date: 2008-10-15 Impact factor: 6.860
Authors: Neco X Johnson; Maria J Marquine; Ilse Flores; Anya Umlauf; Carolyn M Baum; Alex W K Wong; Alexis C Young; Jennifer J Manly; Allen W Heinemann; Susan Magasi; Robert K Heaton Journal: J Int Neuropsychol Soc Date: 2017-06-29 Impact factor: 2.892
Authors: J A Luchsinger; A M Brickman; C Reitz; S J Cho; N Schupf; J J Manly; M X Tang; S A Small; R Mayeux; C DeCarli; T R Brown Journal: Neurology Date: 2009-08-11 Impact factor: 9.910