OBJECTIVE: To investigate the relationship between cerebral blood flow and dementia in older stroke survivors and subjects with Alzheimer disease (AD). METHODS: This cohort study used arterial spin labeling MRI at 3 T to examine cerebral blood flow (CBF). We scanned 39 patients 6 years after stroke. They were older than 75 years at the time of stroke and free of dementia 3 months poststroke, with 8 subsequently developing dementia. We also scanned 17 subjects with AD and 29 healthy control subjects. We determined the perfusion in regions of interest (ROIs). Hippocampal volume was also measured using a previously validated automated procedure. RESULTS: The gray matter/white matter CBF ratio was reduced globally in the poststroke dementia (PSD) group (1.55 SD = 0.12) relative to control subjects (1.78 SD = 0.18; p = 0.03). The CBF ratio in a parietal ROI was reduced in the AD (1.34 SD = 0.31; p = 0.003), PSD (1.32 SD = 0.22; p = 0.041), and poststroke no-dementia (PSND) (1.44 SD = 0.34; p = 0.014) groups relative to that of control subjects (1.70 SD = 0.32). In subjects without stroke, the best predictor of dementia was hippocampus volume, whereas in the stroke group, it was the global CBF gray matter/white matter ratio. Hippocampus volume was not significantly different between the AD and PSD groups, and both had reduced hippocampi relative to those of control subjects and the PSND group. CONCLUSIONS: We found evidence for both vascular and AD pathology in PSD, suggesting that both the direct impact of the stroke and subsequent development of AD-type changes play a role in the etiology of PSD.
OBJECTIVE: To investigate the relationship between cerebral blood flow and dementia in older stroke survivors and subjects with Alzheimer disease (AD). METHODS: This cohort study used arterial spin labeling MRI at 3 T to examine cerebral blood flow (CBF). We scanned 39 patients 6 years after stroke. They were older than 75 years at the time of stroke and free of dementia 3 months poststroke, with 8 subsequently developing dementia. We also scanned 17 subjects with AD and 29 healthy control subjects. We determined the perfusion in regions of interest (ROIs). Hippocampal volume was also measured using a previously validated automated procedure. RESULTS: The gray matter/white matter CBF ratio was reduced globally in the poststroke dementia (PSD) group (1.55 SD = 0.12) relative to control subjects (1.78 SD = 0.18; p = 0.03). The CBF ratio in a parietal ROI was reduced in the AD (1.34 SD = 0.31; p = 0.003), PSD (1.32 SD = 0.22; p = 0.041), and poststroke no-dementia (PSND) (1.44 SD = 0.34; p = 0.014) groups relative to that of control subjects (1.70 SD = 0.32). In subjects without stroke, the best predictor of dementia was hippocampus volume, whereas in the stroke group, it was the global CBF gray matter/white matter ratio. Hippocampus volume was not significantly different between the AD and PSD groups, and both had reduced hippocampi relative to those of control subjects and the PSND group. CONCLUSIONS: We found evidence for both vascular and AD pathology in PSD, suggesting that both the direct impact of the stroke and subsequent development of AD-type changes play a role in the etiology of PSD.
Authors: Per Borghammer; Kristjana Yr Jonsdottir; Paul Cumming; Karen Ostergaard; Kim Vang; Mahmoud Ashkanian; Manoucher Vafaee; Peter Iversen; Albert Gjedde Journal: Neuroimage Date: 2008-01-12 Impact factor: 6.556
Authors: Wen-Chau Wu; Brian L Edlow; Mark A Elliot; Jiongjiong Wang; John A Detre Journal: IEEE Trans Med Imaging Date: 2009-01-13 Impact factor: 10.048
Authors: Norbert Schuff; Shinji Matsumoto; Joseph Kmiecik; Colin Studholme; Antao Du; Frank Ezekiel; Bruce L Miller; Joel H Kramer; William J Jagust; Helen C Chui; Michael W Weiner Journal: Alzheimers Dement Date: 2009-11 Impact factor: 21.566
Authors: Michael J Firbank; Emma J Burton; Robert Barber; Sally Stephens; Rose Anne Kenny; Clive Ballard; Raj N Kalaria; John T O'Brien Journal: Neurobiol Aging Date: 2006-08-24 Impact factor: 4.673
Authors: Quan Zhang; Randall B Stafford; Ze Wang; Steven E Arnold; David A Wolk; John A Detre Journal: J Alzheimers Dis Date: 2012 Impact factor: 4.472
Authors: Axel Montagne; Daniel A Nation; Judy Pa; Melanie D Sweeney; Arthur W Toga; Berislav V Zlokovic Journal: Acta Neuropathol Date: 2016-04-01 Impact factor: 17.088
Authors: Patrick Luckett; Robert H Paul; Jaimie Navid; Sarah A Cooley; Julie K Wisch; Anna H Boerwinkle; Dimitre Tomov; Beau M Ances Journal: J Acquir Immune Defic Syndr Date: 2019-12-15 Impact factor: 3.731
Authors: Louise M Allan; Elise N Rowan; Michael J Firbank; Alan J Thomas; Stephen W Parry; Tuomo M Polvikoski; John T O'Brien; Raj N Kalaria Journal: Brain Date: 2011-12 Impact factor: 13.501
Authors: M J C Burke; L Nelson; J Y Slade; A E Oakley; A A Khundakar; R N Kalaria Journal: Neuropathol Appl Neurobiol Date: 2014-04 Impact factor: 8.090
Authors: Henri J M M Mutsaerts; Edo Richard; Dennis F R Heijtel; Matthias J P van Osch; Charles B L M Majoie; Aart J Nederveen Journal: Neuroimage Clin Date: 2013-11-15 Impact factor: 4.881