Literature DB >> 15665492

Characterization of apoptosis induced by fucoxanthin in human promyelocytic leukemia cells.

Eiichi Kotake-Nara1, Masaru Terasaki, Akihiko Nagao.   

Abstract

Apoptosis induced by fucoxanthin in HL-60 cells was associated with a loss of mitochondrial membrane potential at an early stage, but not with an increase in reactive oxygen species. Fucoxanthin treatment caused cleavages of procaspase-3 and poly (ADP-ribose) polymerase without any effect on the protein level of Bcl-2, Bcl-X(L), or Bax. Apoptosis induction by fucoxanthin may be mediated via mitochondrial membrane permeabilization and caspase-3 activation.

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Year:  2005        PMID： 15665492     DOI： 10.1271/bbb.69.224

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  27 in total

1.  Glyceroglycolipids Affect Uptake of Carotenoids Solubilized in Mixed Micelles by Human Intestinal Caco-2 Cells.

Authors:  Eiichi Kotake-Nara; Lina Yonekura; Akihiko Nagao
Journal:  Lipids       Date:  2015-05-27       Impact factor: 1.880

2.  A highly polar xanthophyll of 9'-cis-neoxanthin induces apoptosis in HCT116 human colon cancer cells through mitochondrial dysfunction.

Authors:  Masaru Terasaki; Akira Asai; Hong Zhang; Akihiko Nagao
Journal:  Mol Cell Biochem       Date:  2006-12-22       Impact factor: 3.842

3.  Fucoxanthin attenuates rifampin-induced cytochrome P450 3A4 (CYP3A4) and multiple drug resistance 1 (MDR1) gene expression through pregnane X receptor (PXR)-mediated pathways in human hepatoma HepG2 and colon adenocarcinoma LS174T cells.

Authors:  Cheng-Ling Liu; Yun-Ping Lim; Miao-Lin Hu
Journal:  Mar Drugs       Date:  2012-01-23       Impact factor: 6.085

Review 4.  Absorption and metabolism of xanthophylls.

Authors:  Eiichi Kotake-Nara; Akihiko Nagao
Journal:  Mar Drugs       Date:  2011-06-10       Impact factor: 6.085

5.  In silico study of fucoxanthin as a tumor cytotoxic agent.

Authors:  Hedi I Januar; Ariyanti S Dewi; Endar Marraskuranto; Thamrin Wikanta
Journal:  J Pharm Bioallied Sci       Date:  2012-01

Review 6.  Fucoxanthin, a marine carotenoid present in brown seaweeds and diatoms: metabolism and bioactivities relevant to human health.

Authors:  Juan Peng; Jian-Ping Yuan; Chou-Fei Wu; Jiang-Hai Wang
Journal:  Mar Drugs       Date:  2011-10-10       Impact factor: 6.085

7.  Fucoxanthin Exerts Anti-Tumor Activity on Canine Mammary Tumor Cells via Tumor Cell Apoptosis Induction and Angiogenesis Inhibition.

Authors:  Hyuk Jang; Jawun Choi; Jeong-Ki Park; Gayeon Won; Jae-Won Seol
Journal:  Animals (Basel)       Date:  2021-05-23       Impact factor: 2.752

8.  In vivo induction of apoptosis by fucoxanthin, a marine carotenoid, associated with down-regulating STAT3/EGFR signaling in sarcoma 180 (S180) xenografts-bearing mice.

Authors:  Jun Wang; Shihui Chen; Shiqiang Xu; Xing Yu; Dongqing Ma; Xiamin Hu; Xiaolu Cao
Journal:  Mar Drugs       Date:  2012-09-20       Impact factor: 6.085

Review 9.  Fucoxanthin and Its Metabolite Fucoxanthinol in Cancer Prevention and Treatment.

Authors:  Luc J Martin
Journal:  Mar Drugs       Date:  2015-07-31       Impact factor: 5.118

Review 10.  Cancer preventive efficacy of marine carotenoid fucoxanthin: cell cycle arrest and apoptosis.

Authors:  Thamaraiselvan Rengarajan; Permaiyan Rajendran; Natarajan Nandakumar; Maruthaiveeran Periyasamy Balasubramanian; Ikuo Nishigaki
Journal:  Nutrients       Date:  2013-12-06       Impact factor: 5.717
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