Literature DB >> 15665489

Ergosterol peroxide, an apoptosis-inducing component isolated from Sarcodon aspratus (Berk.) S. Ito.

Toshiyuki Takei1, Mitsuru Yoshida, Mayumi Ohnishi-Kameyama, Masuko Kobori.   

Abstract

Among the lipophilic extracts of seven traditional edible mushrooms, the acetone extract of Sarcodon aspratus markedly inhibited the growth of HL60 human leukemia cells and induced apoptosis after 24 h incubation. The major active component was identified as ergosterol peroxide by NMR and ESI-MS analysis. Ergosterol peroxide completely inhibited growth and induced apoptosis of HL60 cells at a concentration of 25 microM.

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Year:  2005        PMID： 15665489     DOI： 10.1271/bbb.69.212

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  16 in total

1.  Ergosterol peroxide from an edible mushroom suppresses inflammatory responses in RAW264.7 macrophages and growth of HT29 colon adenocarcinoma cells.

Authors:  M Kobori; M Yoshida; M Ohnishi-Kameyama; H Shinmoto
Journal:  Br J Pharmacol       Date:  2006-12-11       Impact factor: 8.739

2.  Secondary Metabolites and Their Biological Activity from Aspergillus aculeatus KKU-CT2.

Authors:  Natanong Yodsing; Ratsami Lekphrom; Watchara Sangsopha; Tadanori Aimi; Sophon Boonlue
Journal:  Curr Microbiol       Date:  2017-12-16       Impact factor: 2.188

3.  Investigation of the Polyphenol Composition, Biological Activities, and Detoxification Properties of Some Medicinal Mushrooms from Turkey.

Authors:  Naznoosh Shomali; Okan Onar; Tuğçe Alkan; Nergiz Demirtaş; Ilgaz Akata; Özlem Yildirim
Journal:  Turk J Pharm Sci       Date:  2019-03-27

4.  Inhibition of STAT3 signaling and induction of SHP1 mediate antiangiogenic and antitumor activities of ergosterol peroxide in U266 multiple myeloma cells.

Authors:  Yun-Hee Rhee; Soo-Jin Jeong; Hyo-Jeong Lee; Hyo-Jung Lee; Wonil Koh; Ji Hoon Jung; Sun-Hee Kim; Kim Sung-Hoon
Journal:  BMC Cancer       Date:  2012-01-20       Impact factor: 4.430

5.  Upregulation of death receptor 5 and activation of caspase 8/3 play a critical role in ergosterol peroxide induced apoptosis in DU 145 prostate cancer cells.

Authors:  Jonghyun Han; Eun Jung Sohn; Bonglee Kim; Sunhee Kim; Gunho Won; Sangwook Yoon; Jihyun Lee; Moon Joon Kim; Hojin Lee; Kyujin Chung; Sung-Hoon Kim
Journal:  Cancer Cell Int       Date:  2014-11-30       Impact factor: 5.722

Review 6.  Cladosporium cladosporioides from the perspectives of medical and biotechnological approaches.

Authors:  Manaf AlMatar; Essam A Makky
Journal:  3 Biotech       Date:  2015-12-31       Impact factor: 2.406

7.  Ergosterol peroxide activates Foxo3-mediated cell death signaling by inhibiting AKT and c-Myc in human hepatocellular carcinoma cells.

Authors:  Xiangmin Li; Qingping Wu; Ming Bu; Liming Hu; William W Du; Chunwei Jiao; Honghui Pan; Mouna Sdiri; Nan Wu; Yizhen Xie; Burton B Yang
Journal:  Oncotarget       Date:  2016-06-07

8.  Elimination of quiescent slow-cycling cells via reducing quiescence depth by natural compounds purified from Ganoderma lucidum.

Authors:  Jian Dai; Matthew A Miller; Nicholas J Everetts; Xia Wang; Peng Li; Ye Li; Jian-Hua Xu; Guang Yao
Journal:  Oncotarget       Date:  2017-02-21

9.  Inhibition of IKK-β by epidioxysterols from the flowers of Calotropis gigantea (Niu jiao gua).

Authors:  Supawadee Parhira; Guo-Yuan Zhu; Ting Li; Liang Liu; Li-Ping Bai; Zhi-Hong Jiang
Journal:  Chin Med       Date:  2016-03-02       Impact factor: 5.455

10.  A New Method for the Isolation of Ergosterol and Peroxyergosterol as Active Compounds of Hygrophoropsis aurantiaca and in Vitro Antiproliferative Activity of Isolated Ergosterol Peroxide.

Authors:  Renata Nowak; Marta Drozd; Ewaryst Mendyk; Marta Lemieszek; Olga Krakowiak; Wanda Kisiel; Wojciech Rzeski; Katarzyna Szewczyk
Journal:  Molecules       Date:  2016-07-21       Impact factor: 4.411
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