Literature DB >> 15664964

Long-term protection against tuberculosis following vaccination with a severely attenuated double lysine and pantothenate auxotroph of Mycobacterium tuberculosis.

Vasan K Sambandamurthy1, Steven C Derrick, Kripa V Jalapathy, Bing Chen, Robert G Russell, Sheldon L Morris, William R Jacobs.   

Abstract

We report the safety and immunogenicity of a double lysine and pantothenate auxotroph of Mycobacterium tuberculosis in mice. The DeltalysA DeltapanCD mutant is completely attenuated in immunocompromised SCID and gamma interferon knockout mice yet induces short-term and long-term protection in immunocompetent and CD4-deficient mice following single-dose subcutaneous vaccination.

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Year:  2005        PMID： 15664964      PMCID： PMC547051          DOI： 10.1128/IAI.73.2.1196-1203.2005

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  41 in total

1.  Mice deficient in CD4 T cells have only transiently diminished levels of IFN-gamma, yet succumb to tuberculosis.

Authors:  A M Caruso; N Serbina; E Klein; K Triebold; B R Bloom; J L Flynn
Journal:  J Immunol       Date:  1999-05-01       Impact factor: 5.422

2.  Virus-specific CD8(+) T cell numbers are maintained during gamma-herpesvirus reactivation in CD4-deficient mice.

Authors:  P G Stevenson; G T Belz; J D Altman; P C Doherty
Journal:  Proc Natl Acad Sci U S A       Date:  1998-12-22       Impact factor: 11.205

3.  Has BCG attenuated to impotence?

Authors:  M A Behr; P M Small
Journal:  Nature       Date:  1997-09-11       Impact factor: 49.962

4.  Growth rate of mycobacteria in mice as an unreliable indicator of mycobacterial virulence.

Authors:  R J North; L Ryan; R LaCource; T Mogues; M E Goodrich
Journal:  Infect Immun       Date:  1999-10       Impact factor: 3.441

5.  Persistence and protective efficacy of a Mycobacterium tuberculosis auxotroph vaccine.

Authors:  M Jackson; S W Phalen; M Lagranderie; D Ensergueix; P Chavarot; G Marchal; D N McMurray; B Gicquel; C Guilhot
Journal:  Infect Immun       Date:  1999-06       Impact factor: 3.441

6.  Anaerobic nitrate reductase (narGHJI) activity of Mycobacterium bovis BCG in vitro and its contribution to virulence in immunodeficient mice.

Authors:  I Weber; C Fritz; S Ruttkowski; A Kreft; F C Bange
Journal:  Mol Microbiol       Date:  2000-03       Impact factor: 3.501

7.  Impact of pulmonary tuberculosis on survival of HIV-infected adults: a prospective epidemiologic study in Uganda.

Authors:  C C Whalen; P Nsubuga; A Okwera; J L Johnson; D L Hom; N L Michael; R D Mugerwa; J J Ellner
Journal:  AIDS       Date:  2000-06-16       Impact factor: 4.177

8.  Attenuation of and protection induced by a leucine auxotroph of Mycobacterium tuberculosis.

Authors:  M K Hondalus; S Bardarov; R Russell; J Chan; W R Jacobs; B R Bloom
Journal:  Infect Immun       Date:  2000-05       Impact factor: 3.441

9.  Relative contributions of distinct MHC class I-dependent cell populations in protection to tuberculosis infection in mice.

Authors:  A O Sousa; R J Mazzaccaro; R G Russell; F K Lee; O C Turner; S Hong; L Van Kaer; B R Bloom
Journal:  Proc Natl Acad Sci U S A       Date:  2000-04-11       Impact factor: 11.205

10.  Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis.

Authors:  G G Mahairas; P J Sabo; M J Hickey; D C Singh; C K Stover
Journal:  J Bacteriol       Date:  1996-03       Impact factor: 3.490
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  56 in total

1.  Lassomycin, a ribosomally synthesized cyclic peptide, kills mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2.

Authors:  Ekaterina Gavrish; Clarissa S Sit; Shugeng Cao; Olga Kandror; Amy Spoering; Aaron Peoples; Losee Ling; Ashley Fetterman; Dallas Hughes; Anthony Bissell; Heather Torrey; Tatos Akopian; Andreas Mueller; Slava Epstein; Alfred Goldberg; Jon Clardy; Kim Lewis
Journal:  Chem Biol       Date:  2014-03-27

2.  Assessment of Mycobacterium tuberculosis pantothenate kinase vulnerability through target knockdown and mechanistically diverse inhibitors.

Authors:  B K Kishore Reddy; Sudhir Landge; Sudha Ravishankar; Vikas Patil; Vikas Shinde; Subramanyam Tantry; Manoj Kale; Anandkumar Raichurkar; Sreenivasaiah Menasinakai; Naina Vinay Mudugal; Anisha Ambady; Anirban Ghosh; Ragadeepthi Tunduguru; Parvinder Kaur; Ragini Singh; Naveen Kumar; Sowmya Bharath; Aishwarya Sundaram; Jyothi Bhat; Vasan K Sambandamurthy; Christofer Björkelid; T Alwyn Jones; Kaveri Das; Balachandra Bandodkar; Krishnan Malolanarasimhan; Kakoli Mukherjee; Vasanthi Ramachandran
Journal:  Antimicrob Agents Chemother       Date:  2014-03-31       Impact factor: 5.191

Review 3.  Adenylating enzymes in Mycobacterium tuberculosis as drug targets.

Authors:  Benjamin P Duckworth; Kathryn M Nelson; Courtney C Aldrich
Journal:  Curr Top Med Chem       Date:  2012       Impact factor: 3.295

4.  Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis.

Authors:  Joseph Hinchey; Sunhee Lee; Bo Y Jeon; Randall J Basaraba; Manjunatha M Venkataswamy; Bing Chen; John Chan; Miriam Braunstein; Ian M Orme; Steven C Derrick; Sheldon L Morris; William R Jacobs; Steven A Porcelli
Journal:  J Clin Invest       Date:  2007-08       Impact factor: 14.808

5.  Tuberculosis vaccines: current progress.

Authors:  Ian M Orme
Journal:  Drugs       Date:  2005       Impact factor: 9.546

Review 6.  Tuberculosis vaccines in clinical trials.

Authors:  Rosalind Rowland; Helen McShane
Journal:  Expert Rev Vaccines       Date:  2011-05       Impact factor: 5.217

7.  Protective efficacy of a recombinant BCG secreting antigen 85B/Rv3425 fusion protein against Mycobacterium tuberculosis infection in mice.

Authors:  Jiuling Wang; Yaqing Qie; Wei Liu; Honghai Wang
Journal:  Hum Vaccin Immunother       Date:  2012-08-21       Impact factor: 3.452

8.  Characterization of the protective T-cell response generated in CD4-deficient mice by a live attenuated Mycobacterium tuberculosis vaccine.

Authors:  Steven C Derrick; Teresa H Evering; Vasan K Sambandamurthy; Kripa V Jalapathy; Tsungda Hsu; Bing Chen; Mei Chen; Robert G Russell; Ana Paula Junqueira-Kipnis; Ian M Orme; Steven A Porcelli; William R Jacobs; Sheldon L Morris
Journal:  Immunology       Date:  2006-10-31       Impact factor: 7.397

9.  Direct visualization by cryo-EM of the mycobacterial capsular layer: a labile structure containing ESX-1-secreted proteins.

Authors:  Musa Sani; Edith N G Houben; Jeroen Geurtsen; Jason Pierson; Karin de Punder; Maaike van Zon; Brigitte Wever; Sander R Piersma; Connie R Jiménez; Mamadou Daffé; Ben J Appelmelk; Wilbert Bitter; Nicole van der Wel; Peter J Peters
Journal:  PLoS Pathog       Date:  2010-03-05       Impact factor: 6.823

10.  Protective efficacy of BCG overexpressing an L,D-transpeptidase against M. tuberculosis infection.

Authors:  Scott T Nolan; Gyanu Lamichhane
Journal:  PLoS One       Date:  2010-10-29       Impact factor: 3.240
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