Literature DB >> 22906934

Protective efficacy of a recombinant BCG secreting antigen 85B/Rv3425 fusion protein against Mycobacterium tuberculosis infection in mice.

Jiuling Wang1, Yaqing Qie, Wei Liu, Honghai Wang.   

Abstract

In this study, the protective efficacy of a novel recombinant BCG strain co-expressing Ag85B and Rv3425 against Mycobacterium tuberculosis H37Rv was evaluated in mice. This rBCG::Ag85B-Rv3425 strain could provide similar or even better protective efficacy against M. tuberculosis challenge compared with BCG, as shown by no weight loss, significantly reduced lung:body weight ratios and lung bacteria load only at early time of infection. The results suggest that rBCG::Ag85B-Rv3425 could be a potential tuberculosis vaccine candidate for further study.

Entities:  

Keywords:  Rv3425 protein; mycobacterium tuberculosis; recombinant BCG

Mesh：

Substances：

Year:  2012        PMID： 22906934      PMCID： PMC3656079          DOI： 10.4161/hv.21817

Source DB:  PubMed          Journal:  Hum Vaccin Immunother        ISSN： 2164-5515            Impact factor:   3.452


  25 in total

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Review 4.  Determinants of vaccine-induced resistance in animal models of pulmonary tuberculosis.

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Journal:  Scand J Infect Dis       Date:  2001

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Journal:  Int J Epidemiol       Date:  1993-12       Impact factor: 7.196

6.  Comparative genomics of BCG vaccines by whole-genome DNA microarray.

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7.  The efficacy of bacillus Calmette-Guérin vaccination of newborns and infants in the prevention of tuberculosis: meta-analyses of the published literature.

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Journal:  Pediatrics       Date:  1995-07       Impact factor: 7.124

8.  Efficacy of BCG vaccine in the prevention of tuberculosis. Meta-analysis of the published literature.

Authors:  G A Colditz; T F Brewer; C S Berkey; M E Wilson; E Burdick; H V Fineberg; F Mosteller
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9.  PPE antigen Rv2430c of Mycobacterium tuberculosis induces a strong B-cell response.

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10.  Efficacy of BCG vaccination of the newborn: evaluation by a follow-up study of contacts in Bangui.

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  3 in total

1.  Assessment of recombinant plasmid expressing fusion antigen Ag85B-Rv3425 in management of acute tuberculosis infection in mice.

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2.  Prime-boost bacillus Calmette-Guérin vaccination with lentivirus-vectored and DNA-based vaccines expressing antigens Ag85B and Rv3425 improves protective efficacy against Mycobacterium tuberculosis in mice.

Authors:  Ying Xu; Enzhuo Yang; Jianguang Wang; Rui Li; Guanghua Li; Guoyuan Liu; Na Song; Qi Huang; Cong Kong; Honghai Wang
Journal:  Immunology       Date:  2014-10       Impact factor: 7.397

3.  A drug-repositioning screening identifies pentetic acid as a potential therapeutic agent for suppressing the elastase-mediated virulence of Pseudomonas aeruginosa.

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