Literature DB >> 15664846

Active site directed inhibitors of replication-specific bacterial DNA polymerases.

George E Wright1, Neal C Brown, Wei-Chu Xu, Zheng-Yu Long, Chengxin Zhi, Joseph J Gambino, Marjorie H Barnes, Michelle M Butler.   

Abstract

7-Substituted-N(2)-(3,4-dichlorobenzyl)guanines potently and competitively inhibit DNA polymerases IIIC and IIIE from Gram(+) bacteria. Certain derivatives are also competitive inhibitors of DNA polymerase IIIE from Gram(-) bacteria.

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Year:  2005        PMID： 15664846     DOI： 10.1016/j.bmcl.2004.11.016

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  12 in total

1.  Structure of PolC reveals unique DNA binding and fidelity determinants.

Authors:  Ronald J Evans; Douglas R Davies; James M Bullard; Jeffrey Christensen; Louis S Green; Joseph W Guiles; Janice D Pata; Wendy K Ribble; Nebojsa Janjic; Thale C Jarvis
Journal:  Proc Natl Acad Sci U S A       Date:  2008-12-23       Impact factor: 11.205

Review 2.  Challenges of antibacterial discovery.

Authors:  Lynn L Silver
Journal:  Clin Microbiol Rev       Date:  2011-01       Impact factor: 26.132

3.  A novel agent effective against Clostridium difficile infection.

Authors:  Sofya Dvoskin; Wei-Chu Xu; Neal C Brown; Ivan B Yanachkov; Milka Yanachkova; George E Wright
Journal:  Antimicrob Agents Chemother       Date:  2011-12-27       Impact factor: 5.191

4.  7-Alkyl-N(2)-substituted-3-deazaguanines. Synthesis, DNA polymerase III inhibition and antibacterial activity.

Authors:  Wei-Chu Xu; George E Wright; Neal C Brown; Zheng-Yu Long; Cheng-Xin Zhi; Sofya Dvoskin; Joseph J Gambino; Marjorie H Barnes; Michelle M Butler
Journal:  Bioorg Med Chem Lett       Date:  2011-05-30       Impact factor: 2.823

5.  DNA Targeting as a Likely Mechanism Underlying the Antibacterial Activity of Synthetic Bis-Indole Antibiotics.

Authors:  Timothy J Opperman; Steven M Kwasny; Jessica Bo Li; Mark A Lewis; Daniel Aiello; John D Williams; Norton P Peet; Donald T Moir; Terry L Bowlin; Eric C Long
Journal:  Antimicrob Agents Chemother       Date:  2016-11-21       Impact factor: 5.191

6.  Clostridium difficile DNA polymerase IIIC: basis for activity of antibacterial compounds.

Authors:  Andrea Torti; Andrea Lossani; Lida Savi; Federico Focher; George Edward Wright; Neal Curtis Brown; Wei-Chu Xu
Journal:  Curr Enzym Inhib       Date:  2011-10

7.  Design and antimicrobial action of purine analogues that bind Guanine riboswitches.

Authors:  Jane N Kim; Kenneth F Blount; Izabela Puskarz; Jinsoo Lim; Kristian H Link; Ronald R Breaker
Journal:  ACS Chem Biol       Date:  2009-11-20       Impact factor: 5.100

Review 8.  Architecture and conservation of the bacterial DNA replication machinery, an underexploited drug target.

Authors:  Andrew Robinson; Rebecca J Causer; Nicholas E Dixon
Journal:  Curr Drug Targets       Date:  2012-03       Impact factor: 3.465

Review 9.  DNA replication proteins as potential targets for antimicrobials in drug-resistant bacterial pathogens.

Authors:  Erika van Eijk; Bert Wittekoek; Ed J Kuijper; Wiep Klaas Smits
Journal:  J Antimicrob Chemother       Date:  2017-05-01       Impact factor: 5.790

Review 10.  The Macromolecular Machines that Duplicate the Escherichia coli Chromosome as Targets for Drug Discovery.

Authors:  Jon M Kaguni
Journal:  Antibiotics (Basel)       Date:  2018-03-14
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