Literature DB >> 15664807

Syntheses of 2,4,6-trisubstituted triazines as antimalarial agents.

Anu Agarwal1, Kumkum Srivastava, S K Puri, Prem M S Chauhan.   

Abstract

A series of 2,4,6-trisubstituted-1,3,5-triazines (2a-s) were synthesized and evaluated for their in vitro antimalarial activity against P. falciparum. Out of the 19 compounds synthesized eight compounds showed MIC in the range of 1-2 microg/mL. These compounds are in vitro several times more active than cycloguanil.

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Year:  2005        PMID： 15664807     DOI： 10.1016/j.bmcl.2004.11.052

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

1.  Syntheses and Structural Investigations of Penta-Coordinated Co(II) Complexes with Bis-Pyrazolo-S-Triazine Pincer Ligands, and Evaluation of Their Antimicrobial and Antioxidant Activities.

Authors:  Saied M Soliman; Raghdaa A Massoud; Hessa H Al-Rasheed; Ayman El-Faham
Journal:  Molecules       Date:  2021-06-14       Impact factor: 4.411

2.  Synthesis, characterization and evaluation of 1,3,5-triazine aminobenzoic acid derivatives for their antimicrobial activity.

Authors:  Khadijah M Al-Zaydi; Hosam H Khalil; Ayman El-Faham; Sherine N Khattab
Journal:  Chem Cent J       Date:  2017-05-10       Impact factor: 4.215

3.  Synthesis, molecular docking, ctDNA interaction, DFT calculation and evaluation of antiproliferative and anti-Toxoplasma gondii activities of 2,4-diaminotriazine-thiazole derivatives.

Authors:  Krzysztof Z Łączkowski; Joanna Anusiak; Marta Świtalska; Katarzyna Dzitko; Joanna Cytarska; Angelika Baranowska-Łączkowska; Tomasz Plech; Agata Paneth; Joanna Wietrzyk; Joanna Białczyk
Journal:  Med Chem Res       Date:  2018-02-06       Impact factor: 1.965

4.  Design, synthesis and biological evaluation of antimalarial activity of new derivatives of 2,4,6-s-triazine.

Authors:  Mallika Pathak; Himanshu Ojha; Anjani K Tiwari; Deepti Sharma; Manisha Saini; Rita Kakkar
Journal:  Chem Cent J       Date:  2017-12-19       Impact factor: 4.215

5.  Multicomponent Molecular Systems Based on Porphyrins, 1,3,5-Triazine and Carboranes: Synthesis and Characterization.

Authors:  Victoria M Alpatova; Evgeny G Rys; Elena G Kononova; Ekaterina A Khakina; Alina A Markova; Anna V Shibaeva; Vladimir A Kuzmin; Valentina A Ol'shevskaya
Journal:  Molecules       Date:  2022-09-21       Impact factor: 4.927

6.  1,3,5-Triazine Nitrogen Mustards with Different Peptide Group as Innovative Candidates for AChE and BACE1 Inhibitors.

Authors:  Dawid Maliszewski; Agnieszka Wróbel; Beata Kolesińska; Justyna Frączyk; Danuta Drozdowska
Journal:  Molecules       Date:  2021-06-28       Impact factor: 4.411

7.  Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion.

Authors:  Yeon Ja Choi; Yun Jung Park; Ji Young Park; Hyoung Oh Jeong; Dae Hyun Kim; Young Mi Ha; Ji Min Kim; Yu Min Song; Hyoung-Sam Heo; Byung Pal Yu; Pusoon Chun; Hyung Ryong Moon; Hae Young Chung
Journal:  PLoS One       Date:  2012-08-22       Impact factor: 3.240

8.  Crystal structure and Hirshfeld surface analysis of 2,4-di-amino-6-methyl-1,3,5-triazin-1-ium tri-chloro-acetate monohydrate.

Authors:  Ramalingam Sangeetha; Kasthuri Balasubramani; Kaliyaperumal Thanigaimani; Savaridasson Jose Kavitha
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2018-06-12

9.  Synthesis and Preliminary Biological Evaluation of 1,3,5-Triazine Amino Acid Derivatives to Study Their MAO Inhibitors.

Authors:  Sherine N Khattab; Hosam H Khalil; Adnan A Bekhit; Mohamed Mokbel Abd El-Rahman; Ayman El-Faham; Fernando Albericio
Journal:  Molecules       Date:  2015-09-02       Impact factor: 4.411

10.  Melatonin action in Plasmodium infection: Searching for molecules that modulate the asexual cycle as a strategy to impair the parasite cycle.

Authors:  Pedro H S Pereira; Celia R S Garcia
Journal:  J Pineal Res       Date:  2020-10-28       Impact factor: 13.007
  10 in total

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