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Literature DB >> 15663202

Natural vanadium-containing Mt. Fuji ground water improves hypo-activity of liver insulin receptor in Goto-Kakisaki rats.

Katsuhiko Kato¹, Shizuo Yamada, Yuki Ohmori, Tomomi Oki, Eiichi Kawamoto, Kazuhiko Shirama, Yasuo Watanabe.

Abstract

After daily treatments with Mt. Fuji ground water containing natural vanadium (approximately 65 microg/l) at doses of 0.53 microg/kg/day for 12 weeks, blood glucose (BG), serum hemoglobin A1C (HbA1C) levels and insulin secretion from the pancreas of Goto-Kakisaki (GK) rats, a genetic model of Type 2 diabetes, were improved. In GK rat liver insulin receptors, the binding properties of [125I] insulin, and the activities of insulin receptor beta subunit and primary insulin-like growth factor-1beta all recovered to normal levels of those found in Wistar rats. These results suggest that daily treatment with small concentrations of natural vanadium improves hyperglycemia by ameliorating liver insulin receptor activity.

Entities: Chemical Disease Gene Mutation Species

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Year: 2004 PMID： 15663202 DOI： 10.1023/b:mcbi.0000049384.32179.f0

Source DB: PubMed Journal: Mol Cell Biochem ISSN： 0300-8177 Impact factor: 3.396

20 in total

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