| Literature DB >> 15662952 |
Enguerran Vanquelef1, Maryvonne Amoros, Joel Boustie, Michael A Lynch, Roger D Waigh, Olivier Duval.
Abstract
The synthesis of benzo[c]phenanthridine alkaloid derivatives is described. In vitro antiviral activity against herpes simplex type 1 (HSV1) has been investigated. Contrary to the natural product fagaronine, which did not have any activity in the HSV1 antiviral tests, four 12-alkoxy derivatives showed good activity demonstrating the importance of the 12-substitution in the structure-activity relationships.Entities:
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Year: 2004 PMID： 15662952 DOI： 10.1080/14756360412331280518
Source DB: PubMed Journal: J Enzyme Inhib Med Chem ISSN： 1475-6366 Impact factor: 5.051