Literature DB >> 15662507

Tramadol concentrations in blood and in cerebrospinal fluid in a neonate.

K Allegaert1, J de Hoon, R Verbesselt, H Devlieger, D Tibboel.   

Abstract

Based on blood and cerebrospinal fluid samples collected in a full-term neonate, the penetration of tramadol in the central nervous system is described. Following intravenous administration of tramadol, a lag time of about 4 h was observed until full blood-brain equilibration was achieved. This pharmacokinetic observation is in line with a recent pharmacodynamic evaluation of the central opioid effects of tramadol in adults.

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Year:  2005        PMID： 15662507     DOI： 10.1007/s00228-004-0872-7

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  8 in total

1.  Pharmacokinetics of tramadol in children after i.v. or caudal epidural administration.

Authors:  B V Murthy; K S Pandya; P D Booker; A Murray; W Lintz; R Terlinden
Journal:  Br J Anaesth       Date:  2000-03       Impact factor: 9.166

2.  Systematic evaluation of pain in neonates: effect on the number of intravenous analgesics prescribed.

Authors:  Karel Allegaert; Dick Tibboel; Gunnar Naulaers; Denise Tison; Annick De Jonge; Monique Van Dijk; Christine Vanhole; Hugo Devlieger
Journal:  Eur J Clin Pharmacol       Date:  2003-04-04       Impact factor: 2.953

3.  Cerebrospinal fluid pharmacokinetics of paracetamol after intravenous propacetamol in a former preterm infant.

Authors:  K Allegaert; R Verbesselt; H Devlieger; J de Hoon; D Tibboel
Journal:  Br J Clin Pharmacol       Date:  2004-02       Impact factor: 4.335

4.  The pupillary effects of intravenous morphine, codeine, and tramadol in volunteers.

Authors:  Roger D Knaggs; Isla M Crighton; Timothy F Cobby; Anthony J P Fletcher; Gregory J Hobbs
Journal:  Anesth Analg       Date:  2004-07       Impact factor: 5.108

5.  High-performance liquid chromatographic assay for the simultaneous determination of tramadol and its metabolites in microsomal fractions of human liver.

Authors:  W D Paar; P Frankus; H J Dengler
Journal:  J Chromatogr B Biomed Appl       Date:  1996-11-15

6.  Severe cerebral depression after intoxication with tramadol in a 6-month-old infant.

Authors:  F Riedel; H B von Stockhausen
Journal:  Eur J Clin Pharmacol       Date:  1984       Impact factor: 2.953

Review 7.  Tramadol. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in acute and chronic pain states.

Authors:  C R Lee; D McTavish; E M Sorkin
Journal:  Drugs       Date:  1993-08       Impact factor: 9.546

8.  Respiratory and analgesic effects of meperidine and tramadol in patients undergoing orthopedic surgery.

Authors:  R Tarradell; O Pol; M Farré; E Barrera; M M Puig
Journal:  Methods Find Exp Clin Pharmacol       Date:  1996-04
  8 in total

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