| Literature DB >> 15661262 |
Zuzana Zemanova1, Kyra Michalova, Lenka Sindelarova, Petr Smisek, Jana Brezinova, Sarka Ransdorfova, Vladimir Vavra, Alena Dohnalova, Jan Stary.
Abstract
In this study, 107 children with acute lymphoblastic leukemia (ALL) were analysed for the presence of hyperdiploidy by cytogenetics and interphase fluorescence in situ hybridisation (I-FISH). Structural aberrations in hyperdiploid cells were investigated by multiple colour FISH (mFISH). Clones with high hyperdiploidy (>50 chromosomes) (HeH) were found in 46 patients (43%). In nine of these (20%), the abnormal clone was present in <20% of the total cell population. There was no significant difference in EFS between those patients with HeH in 2.5-20% or >20% of cells. Structural rearrangements in the HeH clone were found in 10 patients (22%). In this study, HeH karyotypes containing structural aberrations were an indication of a poor prognosis in childhood ALL.Entities:
Mesh：
Substances：
Year: 2005 PMID： 15661262 DOI： 10.1016/j.leukres.2004.07.004
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156