BACKGROUND: It has been shown that matrix metalloproteinase-9 (MMP-9) is involved in the pathogenesis of various pulmonary inflammatory diseases. We determined the MMP-9 concentration in the plasma of community-acquired pneumonia (CAP) patients before and after antibiotic treatment. METHODS: Gelatin zymography and ELISA analysis were used to measure MMP-9 activity and MMP-9 level, respectively, in 35 control subjects and 46 CAP patients. RESULTS: WBC counts, neutrophils, MMP-9 activity and MMP-9 level were significantly higher in CAP patients compared with that of control subjects (P<0.001), while MMP-9 activity and MMP-9 level were returned to normal after the antibiotic treatment (P<0.001). In addition, MMP-9 level correlated positively with WBC counts and neutrophils number both before and after the antibiotic treatment. CONCLUSIONS: MMP-9 may play an important role in the pathogenesis of CAP with a positive correlation with the number of neutrophils.
BACKGROUND: It has been shown that matrix metalloproteinase-9 (MMP-9) is involved in the pathogenesis of various pulmonary inflammatory diseases. We determined the MMP-9 concentration in the plasma of community-acquired pneumonia (CAP) patients before and after antibiotic treatment. METHODS: Gelatin zymography and ELISA analysis were used to measure MMP-9 activity and MMP-9 level, respectively, in 35 control subjects and 46 CAP patients. RESULTS: WBC counts, neutrophils, MMP-9 activity and MMP-9 level were significantly higher in CAP patients compared with that of control subjects (P<0.001), while MMP-9 activity and MMP-9 level were returned to normal after the antibiotic treatment (P<0.001). In addition, MMP-9 level correlated positively with WBC counts and neutrophils number both before and after the antibiotic treatment. CONCLUSIONS:MMP-9 may play an important role in the pathogenesis of CAP with a positive correlation with the number of neutrophils.
Authors: Christy L Ventura; Roger Higdon; Laura Hohmann; Daniel Martin; Eugene Kolker; H Denny Liggitt; Shawn J Skerrett; Craig E Rubens Journal: Infect Immun Date: 2008-10-13 Impact factor: 3.441
Authors: Tarangini Sathyamoorthy; Gurjinder Sandhu; Liku B Tezera; Richard Thomas; Akul Singhania; Christopher H Woelk; Borislav D Dimitrov; Dan Agranoff; Carlton A W Evans; Jon S Friedland; Paul T Elkington Journal: PLoS One Date: 2015-01-30 Impact factor: 3.240
Authors: Bernhard Schaaf; Cornelia Liebau; Volkhard Kurowski; Daniel Droemann; Klaus Dalhoff Journal: BMC Pulm Med Date: 2008-08-12 Impact factor: 3.317