| Literature DB >> 15646986 |
Amos B Smith1, B Scott Freeze, Matthew J Lamarche, Tomoyasu Hirose, Ignacio Brouard, Ming Xian, Kurt F Sundermann, Simon J Shaw, Mark A Burlingame, Susan Band Horwitz, David C Myles.
Abstract
[Structure: see text] The design, syntheses, and biological evaluation of nine totally synthetic analogues of the microtubule-stabilizing agent (+)-14-normethyldiscodermolide (2) are reported. Simplification at the C(21)-C(24) terminal diene and at the C(1)-C(5) lactone moieties reveals significant structure-activity relationships.Entities:
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Year: 2005 PMID： 15646986 DOI： 10.1021/ol0476873
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005