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Literature DB >> 15645198

Cellular prion protein neuroprotective function: implications in prion diseases.

Abstract

Prion protein can display two conformations: a normal cellular conformation (PrP) and a pathological conformation associated with prion diseases (PrP(Sc)). Three complementary strategies are used by researchers investigating how PrP is involved in the pathogenesis of prion diseases: elucidation of the normal function of PrP, determination of how PrP(Sc) is toxic to neurons, and unraveling the mechanism for the conversion of PrP to PrP(Sc). We review the normal function of PrP as an antioxidant and an antiapoptotic protein in vivo and in vitro. This review also addresses contrasting evidence that PrP is cytotoxic. Finally, we discuss the implication of the neuroprotective role of PrP in prion diseases.

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Year: 2004 PMID： 15645198 DOI： 10.1007/s00109-004-0605-5

Source DB: PubMed Journal: J Mol Med (Berl) ISSN： 0946-2716 Impact factor: 4.599

86 in total

1. Prions prevent neuronal cell-line death.

Authors: C Kuwahara; A M Takeuchi; T Nishimura; K Haraguchi; A Kubosaki; Y Matsumoto; K Saeki; Y Matsumoto; T Yokoyama; S Itohara; T Onodera
Journal: Nature Date: 1999-07-15 Impact factor: 49.962

2. Mutant prion proteins are partially retained in the endoplasmic reticulum.

Authors: L Ivanova; S Barmada; T Kummer; D A Harris
Journal: J Biol Chem Date: 2001-08-29 Impact factor: 5.157

Review 3. Small is not beautiful: antagonizing functions for the prion protein PrP(C) and its homologue Dpl.

Authors: Axel Behrens; Adriano Aguzzi
Journal: Trends Neurosci Date: 2002-03 Impact factor: 13.837

4. Prion protein-deficient cells show altered response to oxidative stress due to decreased SOD-1 activity.

Authors: D R Brown; W J Schulz-Schaeffer; B Schmidt; H A Kretzschmar
Journal: Exp Neurol Date: 1997-07 Impact factor: 5.330

5. Overexpression of PrPc triggers caspase 3 activation: potentiation by proteasome inhibitors and blockade by anti-PrP antibodies.

Authors: E Paitel; C Alves da Costa; D Vilette; J Grassi; F Checler
Journal: J Neurochem Date: 2002-12 Impact factor: 5.372

6. Cellular prion protein status in sheep: tissue-specific biochemical signatures.

Authors: Mohammed Moudjou; Yveline Frobert; Jacques Grassi; Claude La Bonnardière
Journal: J Gen Virol Date: 2001-08 Impact factor: 3.891

7. Conversion of Bcl-2 to a Bax-like death effector by caspases.

Authors: E H Cheng; D G Kirsch; R J Clem; R Ravi; M B Kastan; A Bedi; K Ueno; J M Hardwick
Journal: Science Date: 1997-12-12 Impact factor: 47.728

8. Mice devoid of PrP are resistant to scrapie.

Authors: H Büeler; A Aguzzi; A Sailer; R A Greiner; P Autenried; M Aguet; C Weissmann
Journal: Cell Date: 1993-07-02 Impact factor: 41.582

9. Vascular variant of prion protein cerebral amyloidosis with tau-positive neurofibrillary tangles: the phenotype of the stop codon 145 mutation in PRNP.

Authors: B Ghetti; P Piccardo; M G Spillantini; Y Ichimiya; M Porro; F Perini; T Kitamoto; J Tateishi; C Seiler; B Frangione; O Bugiani; G Giaccone; F Prelli; M Goedert; S R Dlouhy; F Tagliavini
Journal: Proc Natl Acad Sci U S A Date: 1996-01-23 Impact factor: 11.205

10. Transfection of prion protein gene suppresses coxsackievirus B3 replication in prion protein gene-deficient cells.

Authors: Yuko Nakamura; Akikazu Sakudo; Keiichi Saeki; Tomomi Kaneko; Yoshitsugu Matsumoto; Antonio Toniolo; Shigeyoshi Itohara; Takashi Onodera
Journal: J Gen Virol Date: 2003-12 Impact factor: 3.891

49 in total

1. EPR Methods for Biological Cu(II): L-Band CW and NARS.

Authors: Brian Bennett; Jason M Kowalski
Journal: Methods Enzymol Date: 2015-07-23 Impact factor: 1.600

2. Interaction of prion protein with small highly structured RNAs: detection and characterization of PrP-oligomers.

Authors: Sara Vasan; Phyllus Y Mong; Abraham Grossman
Journal: Neurochem Res Date: 2006-06-02 Impact factor: 3.996

Review 3. New molecular insights into cellular survival and stress responses: neuroprotective role of cellular prion protein (PrPC).

Authors: Raymond Yen-Yu Lo; Woei-Cherng Shyu; Shinn-Zong Lin; Hsiao-Jung Wang; Shun-Sheng Chen; Hung Li
Journal: Mol Neurobiol Date: 2007-06 Impact factor: 5.590

Review 4. The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases.

Authors: Konstanze F Winklhofer; Jörg Tatzelt; Christian Haass
Journal: EMBO J Date: 2008-01-23 Impact factor: 11.598

5. Transport of prion protein across the blood-brain barrier.

Authors: W A Banks; Sandra M Robinson; R Diaz-Espinoza; A Urayama; C Soto
Journal: Exp Neurol Date: 2009-05-05 Impact factor: 5.330

Review 6. Biological roles of prion domains.

Authors: Sergey G Inge-Vechtomov; Galina A Zhouravleva; Yury O Chernoff
Journal: Prion Date: 2007 Oct-Dec Impact factor: 3.931

10. Spin hamiltonian parameters for Cu(II)-prion peptide complexes from L-band electron paramagnetic resonance spectroscopy.

Authors: Jason M Kowalski; Brian Bennett
Journal: J Am Chem Soc Date: 2011-01-25 Impact factor: 15.419