Literature DB >> 17917112

New molecular insights into cellular survival and stress responses: neuroprotective role of cellular prion protein (PrPC).

Raymond Yen-Yu Lo1, Woei-Cherng Shyu, Shinn-Zong Lin, Hsiao-Jung Wang, Shun-Sheng Chen, Hung Li.   

Abstract

Knowledge of the physiological function of cellular prion protein has been acquired from prion diseases such as Creutzfeldt-Jakob disease, as well as PRNP knock out and transgenic mice. Recent progress in neurobiology has further delineated the neuroprotective role played by cellular prion protein. In this paper, we review the role of cellular prion protein in cell survival including its antiapoptotic effect on Bax-mediated cell death and its responses to various environmental stresses including oxidative stress, and ischemia. Finally, we discuss the significance of cellular prion protein in different neurodegenerative diseases and the possible development of future therapies.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17917112     DOI： 10.1007/s12035-007-8003-y

Source DB:  PubMed          Journal:  Mol Neurobiol        ISSN： 0893-7648            Impact factor:   5.590


  101 in total

Review 1.  Cellular prion protein: on the road for functions.

Authors:  Vilma R Martins; Rafael Linden; Marco A M Prado; Roger Walz; Américo C Sakamoto; Ivan Izquierdo; Ricardo R Brentani
Journal:  FEBS Lett       Date:  2002-02-13       Impact factor: 4.124

2.  Prion protein-deficient cells show altered response to oxidative stress due to decreased SOD-1 activity.

Authors:  D R Brown; W J Schulz-Schaeffer; B Schmidt; H A Kretzschmar
Journal:  Exp Neurol       Date:  1997-07       Impact factor: 5.330

3.  Recombinant prion protein induces rapid polarization and development of synapses in embryonic rat hippocampal neurons in vitro.

Authors:  Jamil Kanaani; Stanley B Prusiner; Julia Diacovo; Steinunn Baekkeskov; Giuseppe Legname
Journal:  J Neurochem       Date:  2005-12       Impact factor: 5.372

4.  Effects of copper on survival of prion protein knockout neurons and glia.

Authors:  D R Brown; B Schmidt; H A Kretzschmar
Journal:  J Neurochem       Date:  1998-04       Impact factor: 5.372

5.  Overexpression of PrPc triggers caspase 3 activation: potentiation by proteasome inhibitors and blockade by anti-PrP antibodies.

Authors:  E Paitel; C Alves da Costa; D Vilette; J Grassi; F Checler
Journal:  J Neurochem       Date:  2002-12       Impact factor: 5.372

6.  Abnormal synaptic protein expression and cell death in murine scrapie.

Authors:  S Sisó; B Puig; R Varea; E Vidal; C Acín; M Prinz; F Montrasio; J Badiola; A Aguzzi; M Pumarola; I Ferrer
Journal:  Acta Neuropathol       Date:  2002-02-26       Impact factor: 17.088

7.  The cellular prion protein modulates phagocytosis and inflammatory response.

Authors:  Cecília J G de Almeida; Luciana B Chiarini; Juliane Pereira da Silva; Patrícia M R E Silva; Marco Aurélio Martins; Rafael Linden
Journal:  J Leukoc Biol       Date:  2004-11-11       Impact factor: 4.962

8.  Upregulation of cellular prion protein (PrPc) after focal cerebral ischemia and influence of lesion severity.

Authors:  Jens Weise; Olaf Crome; Raoul Sandau; Walter Schulz-Schaeffer; Mathias Bähr; Inga Zerr
Journal:  Neurosci Lett       Date:  2004-11-30       Impact factor: 3.046

9.  PrP(106-126) activates neuronal intracellular kinases and Egr1 synthesis through activation of NADPH-oxidase independently of PrPc.

Authors:  Rosalina Gavín; Nathalie Braun; Oriol Nicolas; Beatriz Parra; Jesus Mariano Ureña; Ana Mingorance; Eduardo Soriano; Juan María Torres; Adriano Aguzzi; José Antonio del Río
Journal:  FEBS Lett       Date:  2005-08-01       Impact factor: 4.124

10.  Mice devoid of PrP are resistant to scrapie.

Authors:  H Büeler; A Aguzzi; A Sailer; R A Greiner; P Autenried; M Aguet; C Weissmann
Journal:  Cell       Date:  1993-07-02       Impact factor: 41.582
View more
  9 in total

Review 1.  Prion protein at the crossroads of physiology and disease.

Authors:  Emiliano Biasini; Jessie A Turnbaugh; Ursula Unterberger; David A Harris
Journal:  Trends Neurosci       Date:  2011-12-01       Impact factor: 13.837

Review 2.  Redox control of prion and disease pathogenesis.

Authors:  Neena Singh; Ajay Singh; Dola Das; Maradumane L Mohan
Journal:  Antioxid Redox Signal       Date:  2010-06-01       Impact factor: 8.401

3.  Knockout of the prion protein (PrP)-like Sprn gene does not produce embryonic lethality in combination with PrP(C)-deficiency.

Authors:  Nathalie Daude; Serene Wohlgemuth; Rebecca Brown; Rose Pitstick; Hristina Gapeshina; Jing Yang; George A Carlson; David Westaway
Journal:  Proc Natl Acad Sci U S A       Date:  2012-05-22       Impact factor: 11.205

4.  Homodimerization as a molecular switch between low and high efficiency PrP C cell surface delivery and neuroprotective activity.

Authors:  Maxime Béland; Xavier Roucou
Journal:  Prion       Date:  2013-01-28       Impact factor: 3.931

Review 5.  Regulation of PrP(C) signaling and processing by dimerization.

Authors:  Xavier Roucou
Journal:  Front Cell Dev Biol       Date:  2014-10-09

Review 6.  Prion protein and aging.

Authors:  Lisa Gasperini; Giuseppe Legname
Journal:  Front Cell Dev Biol       Date:  2014-08-29

7.  Redox processes in neurodegenerative disease involving reactive oxygen species.

Authors:  Peter Kovacic; Ratnasamy Somanathan
Journal:  Curr Neuropharmacol       Date:  2012-12       Impact factor: 7.363

8.  Therapeutic Assay with the Non-toxic C-Terminal Fragment of Tetanus Toxin (TTC) in Transgenic Murine Models of Prion Disease.

Authors:  Rosario Osta; Rosa Bolea; Inmaculada Martín-Burriel; Marina Betancor; Laura Moreno-Martínez; Óscar López-Pérez; Alicia Otero; Adelaida Hernaiz; Tomás Barrio; Juan José Badiola
Journal:  Mol Neurobiol       Date:  2021-07-20       Impact factor: 5.590

9.  Role of cellular prion protein in splenic CD4+ T cell differentiation in cerebral ischaemic/reperfusion.

Authors:  Baizhuo Zhang; Xiang Yin; Yue Lang; Xiaoou Han; Jie Shao; Rongrong Bai; Li Cui
Journal:  Ann Clin Transl Neurol       Date:  2021-09-15       Impact factor: 4.511
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.