Literature DB >> 15643857

Dendrimeric gadolinium chelate with fast water exchange and high relaxivity at high magnetic field strength.

Valérie C Pierre1, Mauro Botta, Kenneth N Raymond.   

Abstract

The synthesis and relaxivity properties of a new dendrimeric Gd chelate, Gd-TREN-bisHOPO-TAM-Asp-Asp2-12OH, are presented. The macromolecule demonstrates improved water solubility due to its 12 terminal hydroxyl groups and improved relaxivity due to its optimal water exchange rate and slower molecular tumbling. Unprecedented high relaxivity (r1p = 18 mM-1 s-1) is observed at high magnetic field (90 MHz), an important advance in the development of contrast agents for the next generation of MRI scanners.

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Year:  2005        PMID： 15643857     DOI： 10.1021/ja045263y

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  19 in total

1.  Strategies for the preparation of bifunctional gadolinium(III) chelators.

Authors:  Luca Frullano; Peter Caravan
Journal:  Curr Org Synth       Date:  2011-08-01       Impact factor: 1.975

Review 2.  Synthetic approaches to heterocyclic ligands for Gd-based MRI contrast agents.

Authors:  Elena Pérez-Mayoral; Jordi Soler-Padrós; Viviana Negri; Sebastián Cerdán; Paloma Ballesteros
Journal:  Molecules       Date:  2007-08-09       Impact factor: 4.411

3.  Metal-containing and related polymers for biomedical applications.

Authors:  Yi Yan; Jiuyang Zhang; Lixia Ren; Chuanbing Tang
Journal:  Chem Soc Rev       Date:  2016-02-24       Impact factor: 54.564

4.  Contrast agents for MRI: 30+ years and where are we going?

Authors:  Valérie C Pierre; Matthew J Allen; Peter Caravan
Journal:  J Biol Inorg Chem       Date:  2014-01-11       Impact factor: 3.358

5.  Improving T₁ and T₂ magnetic resonance imaging contrast agents through the conjugation of an esteramide dendrimer to high-water-coordination Gd(III) hydroxypyridinone complexes.

Authors:  Piper J Klemm; William C Floyd; Danil E Smiles; Jean M J Fréchet; Kenneth N Raymond
Journal:  Contrast Media Mol Imaging       Date:  2012 Jan-Feb       Impact factor: 3.161

6.  Substituent effects on Gd(III)-based MRI contrast agents: optimizing the stability and selectivity of the complex and the number of coordinated water molecules.

Authors:  Valérie C Pierre; Mauro Botta; Silvio Aime; Kenneth N Raymond
Journal:  Inorg Chem       Date:  2006-10-02       Impact factor: 5.165

7.  Multivalent, high-relaxivity MRI contrast agents using rigid cysteine-reactive gadolinium complexes.

Authors:  Praveena D Garimella; Ankona Datta; Dante W Romanini; Kenneth N Raymond; Matthew B Francis
Journal:  J Am Chem Soc       Date:  2011-08-26       Impact factor: 15.419

8.  Eu(II)-containing cryptates as contrast agents for ultra-high field strength magnetic resonance imaging.

Authors:  Joel Garcia; Jaladhar Neelavalli; E Mark Haacke; Matthew J Allen
Journal:  Chem Commun (Camb)       Date:  2011-11-02       Impact factor: 6.222

9.  Synthesis and chemical reactivity of a 6-Me-3,2-hydroxypyridinone dithiazolide with primary amines: a route to new hexadentate chelators for hard metal(III) ions.

Authors:  Sylvie L Pailloux; Sean Nguyen; Stephanie Zhou; Marisa E Hom; Michelle N Keyser; Danil Smiles; Kenneth N Raymond
Journal:  J Heterocycl Chem       Date:  2015-06-04       Impact factor: 2.193

10.  Analysis of Lanthanide Complex Dendrimer Conjugates for Bimodal NIR and MRI Imaging.

Authors:  Christopher M Andolina; Piper J Klemm; William C Floyd; Jean M J Fréchet; Kenneth N Raymond
Journal:  Macromolecules       Date:  2012-11-12       Impact factor: 5.985
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