A hydroxypyridinone building block, bifunctionalized with thiazoline, has been prepared from orthogonally protected 2-(3-(benzyloxy)-4-(ethoxycarbonyl)-6-methyl-2-oxopyridin-1(2H)-yl) acetic acid. The reactivity of the dithiazolide has been explored with two primary amines, leading to the synthesis and characterization of four new hexadentate ligands. Their complexes with selected hard trivalent ions pertinent to potential molecular imaging applications have been surveyed.
A hydroxypyridinone building block, bifunctionalized with n class="Chemical">thiazoline, has been prepared from orthogonally protected 2-(3-(benzyloxy)-4-(ethoxycarbonyl)-6-methyl-2-oxopyridin-1(2H)-yl) acetic acid. The reactivity of the dithiazolide has been explored with two primary amines, leading to the synthesis and characterization of four new hexadentate ligands. Their complexes with selected hard trivalent ions pertinent to potential molecular imaging applications have been surveyed.
Authors: Maria A Telpoukhovskaia; Cristina Rodríguez-Rodríguez; Jacqueline F Cawthray; Lauren E Scott; Brent D G Page; Jorge Alí-Torres; Mariona Sodupe; Gwendolyn A Bailey; Brian O Patrick; Chris Orvig Journal: Metallomics Date: 2014-02 Impact factor: 4.526
Authors: William C Floyd; Piper J Klemm; Danil E Smiles; Ayano C Kohlgruber; Valérie C Pierre; Justin L Mynar; Jean M J Fréchet; Kenneth N Raymond Journal: J Am Chem Soc Date: 2011-02-04 Impact factor: 15.419
Authors: Eric J Werner; Stefano Avedano; Mauro Botta; Benjamin P Hay; Evan G Moore; Silvio Aime; Kenneth N Raymond Journal: J Am Chem Soc Date: 2007-01-30 Impact factor: 15.419