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Literature DB >> 15638787

Recent progress in structure activity relationship and mechanistic studies of taxol analogues.

Abstract

Structure activity relationship (SAR) and mechanism of paclitaxel and its analogues in recent years are discussed in the following areas: SAR of paclitaxel analogues toward "normal" and multi-drug resistance tumors; paclitaxel prodrugs with improved water solubitily and specificity; mechanism of paclitaxel related to tubulin binding and quest for its pharmacophore.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2005 PMID： 15638787 DOI： 10.2174/1389557053402837

Source DB: PubMed Journal: Mini Rev Med Chem ISSN： 1389-5575 Impact factor: 3.862

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Cited

8 in total

Review 1. Natural products as leads to anticancer drugs.

Authors: M Gordaliza
Journal: Clin Transl Oncol Date: 2007-12 Impact factor: 3.405

2. Rotational-echo double-resonance NMR distance measurements for the tubulin-bound Paclitaxel conformation.

Authors: Younkee Paik; Chao Yang; Belhu Metaferia; Shoubin Tang; Susan Bane; Rudravajhala Ravindra; Natasha Shanker; Ana A Alcaraz; Scott A Johnson; Jacob Schaefer; Robert D O'Connor; Lynette Cegelski; James P Snyder; David G I Kingston
Journal: J Am Chem Soc Date: 2007-01-17 Impact factor: 15.419

Review 3. The shape of things to come: structural and synthetic studies of taxol and related compounds.

Authors: David G I Kingston
Journal: Phytochemistry Date: 2006-12-20 Impact factor: 4.072

4. Synthesis and bioactivity of a side chain bridged paclitaxel: A test of the T-Taxol conformation.

Authors: Mathis Hodge; Qiao-Hong Chen; Susan Bane; Shubhada Sharma; Maura Loew; Abhijit Banerjee; Ana A Alcaraz; James P Snyder; David G I Kingston
Journal: Bioorg Med Chem Lett Date: 2009-03-21 Impact factor: 2.823

5. Molecular-docking-guided design, palladium-catalyzed synthesis and anticancer activity of paclitaxel-benzoxazoles hybrids.

Authors: Ting Jiang; Ya-Nan Cao; Jin-Bu Xu; Feng Gao; Ling-Li Zheng
Journal: Sci Rep Date: 2022-06-15 Impact factor: 4.996

Recent progress in structure activity relationship and mechanistic studies of taxol analogues.

Review 1. Natural products as leads to anticancer drugs.

2. Rotational-echo double-resonance NMR distance measurements for the tubulin-bound Paclitaxel conformation.

Review 3. The shape of things to come: structural and synthetic studies of taxol and related compounds.

4. Synthesis and bioactivity of a side chain bridged paclitaxel: A test of the T-Taxol conformation.

5. Molecular-docking-guided design, palladium-catalyzed synthesis and anticancer activity of paclitaxel-benzoxazoles hybrids.

6. The quest for a simple bioactive analog of paclitaxel as a potential anticancer agent.

7. Bioorthogonal Uncaging of Cytotoxic Paclitaxel through Pd Nanosheet-Hydrogel Frameworks.

Review 8. Current Perspectives on Taxanes: Focus on Their Bioactivity, Delivery and Combination Therapy.