| Literature DB >> 15638325 |
Renata L A Furlan1, Stephen J Watt, Leandro M Garrido, Gustavo P Amarante-Mendes, Mohammad Nur-e-alam, Jurgen Rohr, Alfredo Braña, Carmen Mendez, Jose A Salas, Margaret M Sheil, Jennifer L Beck, Gabriel Padilla.
Abstract
Cosmomycin D (CosD) is the major constituent fraction isolated from a culture of Streptomyces olindensis ICB20. The ability of this compound to intercalate with double-stranded DNA was studied by gel mobility shift assays and electrospray ionization mass spectrometry (ESI-MS). ESI-MS experiments showed that the complex of CosD with 16-mer double-stranded DNA was at least as stable as a complex of daunorubicin with the same DNA sequence. This is the first study showing DNA binding properties of an anthracycline containing a beta-rhodomycinone aglycone chromophore O-linked to two trisaccharide chains.Entities:
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Year: 2004 PMID： 15638325 DOI： 10.7164/antibiotics.57.647
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649