Literature DB >> 15638323

Structure of tyroscherin, an antitumor antibiotic against IGF-1-dependent cells from Pseudallescheria sp.

Yoichi Hayakawa1, Tomoki Yamashita, Toshiya Mori, Koji Nagai, Kazuo Shin-Ya, Hidenori Watanabe.   

Abstract

An antitumor antibiotic, tyroscherin, was isolated from the culture of a fungus identified as Pseudallescheria sp. The structure of tyroscherin including the absolute stereochemistry was determined as shown in Fig. 1 by NMR and degradation studies. Tyroscherin selectively inhibited IGF-1-dependent growth of MCF-7 human breast cancer cells with an IC50 of 9.7 ng/ml.

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Year:  2004        PMID： 15638323     DOI： 10.7164/antibiotics.57.634

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  7 in total

Review 1.  Proteomics as a Tool to Identify New Targets Against Aspergillus and Scedosporium in the Context of Cystic Fibrosis.

Authors:  Andoni Ramirez-Garcia; Aize Pellon; Idoia Buldain; Aitziber Antoran; Aitana Arbizu-Delgado; Xabier Guruceaga; Aitor Rementeria; Fernando L Hernando
Journal:  Mycopathologia       Date:  2017-05-08       Impact factor: 2.574

2.  Unexpected stereochemical tolerance for the biological activity of tyroscherin.

Authors:  Hyun Seop Tae; John Hines; Ashley R Schneekloth; Craig M Crews
Journal:  Bioorg Med Chem       Date:  2011-01-19       Impact factor: 3.641

3.  Total synthesis and biological evaluation of tyroscherin.

Authors:  Hyun Seop Tae; John Hines; Ashley R Schneekloth; Craig M Crews
Journal:  Org Lett       Date:  2010-10-01       Impact factor: 6.005

4.  Phylogenetic and chemical diversity of fungal endophytes isolated from Silybum marianum (L) Gaertn. (milk thistle).

Authors:  Huzefa A Raja; Amninder Kaur; Tamam El-Elimat; Mario Figueroa; Rahul Kumar; Gagan Deep; Rajesh Agarwal; Stanley H Faeth; Nadja B Cech; Nicholas H Oberlies
Journal:  Mycology       Date:  2015-02-23

5.  UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genes.

Authors:  Michelle Yi-Xiu Lim; Gregory LaMonte; Marcus C S Lee; Christin Reimer; Bee Huat Tan; Victoria Corey; Bianca F Tjahjadi; Adeline Chua; Marie Nachon; René Wintjens; Peter Gedeck; Benoit Malleret; Laurent Renia; Ghislain M C Bonamy; Paul Chi-Lui Ho; Bryan K S Yeung; Eric D Chow; Liting Lim; David A Fidock; Thierry T Diagana; Elizabeth A Winzeler; Pablo Bifani
Journal:  Nat Microbiol       Date:  2016-09-19       Impact factor: 17.745

6.  Vitroprocines, new antibiotics against Acinetobacter baumannii, discovered from marine Vibrio sp. QWI-06 using mass-spectrometry-based metabolomics approach.

Authors:  Chih-Chuang Liaw; Pei-Chin Chen; Chao-Jen Shih; Sung-Pin Tseng; Ying-Mi Lai; Chi-Hsin Hsu; Pieter C Dorrestein; Yu-Liang Yang
Journal:  Sci Rep       Date:  2015-08-04       Impact factor: 4.379

7.  Mutations in the Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL) Confer Multidrug Resistance.

Authors:  Gregory LaMonte; Michelle Yi-Xiu Lim; Melanie Wree; Christin Reimer; Marie Nachon; Victoria Corey; Peter Gedeck; David Plouffe; Alan Du; Nelissa Figueroa; Bryan Yeung; Pablo Bifani; Elizabeth A Winzeler
Journal:  MBio       Date:  2016-07-05       Impact factor: 7.867
  7 in total

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